Protein Alignment ITK and CG3277

DIOPT Version :10

• Sequence 1: NP_005537.3
• Gene: ITK / 3702
• HGNCID: 6171
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_608762.3
• Gene: CG3277 / 33543
• FlyBaseID: FBgn0031518
• Length: 789
• Species: Drosophila melanogaster
• Alignment Length: 711
• Identity: 156/711 - (21%)
• Similarity: 255/711 - (35%)
• Gaps: 273/711 - (38%)

Human    71 SIPCHYKY--PFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPK----YHPNFWMDGK 129
            |:.|:|.:  .:||:                          ...:|::|.:    |.|. .::||
  Fly   159 SVDCNYMFGCQYQVI--------------------------VETSNAMVRRSARVYIPQ-CLEGK 196

Human   130 WRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIAL--------------Y 180
              |..||                  .|.||......:.|  ..||:.|.|              :
  Fly   197 --CSCQL------------------APTPPKVLAVAKML--SNETISINLSILASELLRKEQDSH 239

Human   181 DYQTNDPQELALRRNEEYCLLDSSEIHW-----------WRVQDRN------GHEGYVP---SSY 225
            .::|....::.|:.|||    .:..:.|           :::.:.|      |.||.:.   .:.
  Fly   240 LHETLRTYKMQLKINEE----TNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEGVMKLGLGTQ 300

Human   226 LVEKSPNNLETYEWYNKSISRDKAEKLLLD-TGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPC 289
            |.||:..:|:.               :::| ||.||...|              ||..|..|...
  Fly   301 LKEKASLSLQA---------------VIIDPTGCEGPRSV--------------TKVPVPANPVL 336

Human   290 IKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLR-- 352
            :..      .|:.....:....:..:|.|         .||:..|     ..|::|..||.||
  Fly   337 LTE------GDSVSNSIIVMSAMLIAIIL---------AGLIMLL-----LRRRRARTTAKLRKQ 381

Human   353 --------------------YGKWVIDPSELTFVQEI--------------GSGQFGLVHLGYWL 383
                                |....::.|::..:.:|              |.|.||.||....:
  Fly   382 EQIYIQTFATSAIEMEDNVNYVDKYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAI 446

Human   384 NKDK------VAIKTIREGAMSEE--DFIEEAEVMMKL-SHPKLVQLYGVCLEQAPICLVFEFME 439
            |..:      ||:|.::....::|  :::.|.|::..: :|..:|...|.|..:.|..::.|::.
  Fly   447 NLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVN 511

Human   440 HGCLSDYLRTQR----------------------------------------------------- 451
            .|.|..||||.|
  Fly   512 KGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDS 576

Human   452 -----GL------FAAET------------------LLGMCLDVCEGMAYLEEACVIHRDLAARN 487
                 |:      ||..|                  |....|.:..||.:|||..:.||||||||
  Fly   577 TAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARN 641

Human   488 CLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVF 552
            .|:..|:.:|:||||::|..:   ||::...|.|::|.|.|....:.||||||:|::||::||:.
  Fly   642 VLIDSNKTLKISDFGLSRHGI---YTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIG 703

Human   553 SEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLA 613
            :.|..||...||.|::..:..|.||.:|.:.:..||.||..||.|.||:||.|..|.:.|:
  Fly   704 TLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVLS 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITK	NP_005537.3	PH_Btk	7..148	CDD:269944	14/82 (17%)
		SH3_ITK	174..229	CDD:212841	14/88 (16%)
		SH2_Tec_Itk	232..340	CDD:198259	17/108 (16%)
		PTKc_Itk	358..613	CDD:133243	96/359 (27%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	94/335 (28%)