Protein Alignment ITK and hop

DIOPT Version :10

• Sequence 1: NP_005537.3
• Gene: ITK / 3702
• HGNCID: 6171
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_511119.2
• Gene: hop / 32080
• FlyBaseID: FBgn0004864
• Length: 1177
• Species: Drosophila melanogaster
• Alignment Length: 751
• Identity: 178/751 - (23%)
• Similarity: 292/751 - (38%)
• Gaps: 205/751 - (27%)

Human     4 FILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKAS---LAYFEDRHGKKRTLKGSIELSRIKCVEI 65
            :|.:..:::.|...:.|.....|:    ::.|.|   |:|....|    .|....|::     .|
  Fly   470 YIDINTKIMAKKTDQERCKTETFR----IVRKDSQWKLSYNNGEH----VLNSLHEVA-----HI 521

Human    66 VKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKE---ETRNNNSLVPK----YHPN 123
            :::|  .|..|:.|........||.:..|.....::..|.|.|   :.||.....|:    ::|:
  Fly   522 IQAD--SPDRYRIPASKYDKPPLLLLLLPKNLKAKKTDLQLSEAELQRRNPQIFNPRTDLQWYPD 584

Human   124 ----------FWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEET---- 174
                      |.|.|.|             .|..|.|:.|........:.|....:...:|
  Fly   585 SISLSDDGMMFTMRGDW-------------IQQSPVKDVSVTMKMLKSDGNFMEFFRLAQTWSLI 636

Human   175 ---VVIALYDYQTNDPQELALRRNEE---------------YCLLDSSE-----IHWWRVQDRNG 216
               ..:.||.....||..:.:..:..               :||||...     :|:  ::|...
  Fly   637 QSPQFLKLYGLTLADPYTMVMEYSRYGPLNKFLHSMPNVTLHCLLDLMHGLVRGMHY--LEDNKI 699

Human   217 HEGYV-----------PSSYLVE---------------KSP-------NNLET------------ 236
            ...|:           |:||:::               .||       .||:.
  Fly   700 IHNYIRCSNLYVTKYDPNSYVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQAAKTDQFAQLWAF 764

Human   237 ----YEWYNK---SISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYH 294
                ||.:::   .:|..:.|:||.....:|..:                |.:..:..|.    .
  Fly   765 ATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNIL----------------KMLDQDICPA----P 809

Human   295 IKET------NDNPKRYYVAEKYVFDSI-----PLLINYH-----QHNGGG---LVTRLRYP-VC 339
            |.||      :|..||:  :...:|..:     .:|.||.     ..||.|   ::.|...| :.
  Fly   810 IFETIMDGWSDDETKRF--SHHDIFSRLNTIKAEILPNYMPPPEIATNGTGDETVIDRSDIPFLP 872

Human   340 FGRQK----APVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDK------VAIKTIR 394
            |.|..    .|:|:..|    ||...|    ..||.|.:|.|:.|:....||      ||||.:.
  Fly   873 FPRSNMLMVIPLTSECR----VIYNME----NMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLN 929

Human   395 EGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETL 459
            ...:| .||..|..:|..||||.:|: :....|::. |::.|:::.|....|||..........|
  Fly   930 TMQVS-TDFHREIGIMRTLSHPNIVK-FKYWAEKSH-CIIMEYLQSGSFDIYLRFTAPNLNNPRL 991

Human   460 LGMCLDVCEGMAYLEEACVIHRDLAARNCLV---GENQVIKVSDFGMTRFV-LDDQYTSSTGTKF 520
            :...||:..||.||.:..:|||||||||.||   |:...:|:||||:.:|. .|..|.:.:....
  Fly   992 VSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDI 1056

Human   521 PVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGK----IPYENRSNSEVVEDISTGFRLYKPR 581
            |::|.|||..|..|:||.|||||:||.::|:||.|:    :|.:. |..:.:..:.:|.||.:|.
  Fly  1057 PIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQT-SQEDFLNRLQSGERLNRPA 1120

Human   582 LASTHVYQIMNHCWKERPEDRPAFSRLL----RQLA 613
            .....:|.:|..||...|..||:|:.::    |::|
  Fly  1121 SCPDFIYDLMQLCWHATPRSRPSFATIVDIITREVA 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITK	NP_005537.3	PH_Btk	7..148	CDD:269944	30/160 (19%)
		SH3_ITK	174..229	CDD:212841	15/107 (14%)
		SH2_Tec_Itk	232..340	CDD:198259	26/146 (18%)
		PTKc_Itk	358..613	CDD:133243	93/272 (34%)
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177	10/53 (19%)
		PTK_Jak_rpt1	584..836	CDD:270633	44/288 (15%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	95/280 (34%)