Protein Alignment ITK and sev

DIOPT Version :10

• Sequence 1: NP_005537.3
• Gene: ITK / 3702
• HGNCID: 6171
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Alignment Length: 483
• Identity: 147/483 - (30%)
• Similarity: 222/483 - (45%)
• Gaps: 89/483 - (18%)

Human   169 WEPEETVVIALYDYQTNDPQELALRRNEEY-CL---LDSSEIHWWRVQDRNGHEGYVPSSYLVEK 229
            |..|..||         :.|.|......|. |:   |.||.:..:||:.|:...|:.|.|   |:
  Fly  2057 WAEEPVVV---------EDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYS---EE 2109

Human   230 SPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYH 294
            |....|.:      :|.:|...|:|                    ..:...|:||.   |:  ..
  Fly  2110 SERVAEPF------VSPEKRGSLVL--------------------AIIAPAAIVSS---CV--LA 2143

Human   295 IKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVT-------AGLR 352
            :.......||...|:|.:..|.|.:.:    |...|.|:.:....  |.:|..|       |.|.
  Fly  2144 LVLVRKVQKRRLRAKKLLQQSRPSIWS----NLSTLQTQQQLMAV--RNRAFSTTLSDADIALLP 2202

Human   353 YGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKD-----KVAIKTIREGAMSEEDFIEEAEVMMK 412
            ...|    |:|..::.:|||.||.|:.|....:|     :||||::|:||....:.::||::|..
  Fly  2203 QINW----SQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSN 2263

Human   413 LSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQR-----------GLFAAETLLGMCLDV 466
            ..|..:|.|.|:|.:...|.|:.|.||.|.|..|||..|           ||..:| ||.||:||
  Fly  2264 FKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSE-LLAMCIDV 2327

Human   467 CEGMAYLEEACVIHRDLAARNCLVGEN-------QVIKVSDFGMTRFVLDDQYTSSTGT-KFPVK 523
            ..|.:|||:...:|||||.|||||.|:       :.:|:.|||:.|.:....|....|. ..||:
  Fly  2328 ANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVR 2392

Human   524 WASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVY 588
            |.|||......::::||||:||||.||:.:.|:.||..|:|.||:..:..|.||.:|.:.:..:|
  Fly  2393 WMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLY 2457

Human   589 QIMNHCWKERPEDRPAFSRLLRQLAEIA 616
            .::..||:..|.:||:|.|....|..|:
  Fly  2458 SLLLLCWRTDPWERPSFRRCYNTLHAIS 2485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITK	NP_005537.3	PH_Btk	7..148	CDD:269944
		SH3_ITK	174..229	CDD:212841	15/58 (26%)
		SH2_Tec_Itk	232..340	CDD:198259	18/107 (17%)
		PTKc_Itk	358..613	CDD:133243	102/278 (37%)
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996
		FN3	1993..2111	CDD:238020	18/65 (28%)
		PTKc_c-ros	2213..2483	CDD:270640	101/270 (37%)