Protein Alignment Hyccin and HYCC1

DIOPT Version :10

• Sequence 1: NP_611256.1
• Gene: Hyccin / 37019
• FlyBaseID: FBgn0034269
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_115970.2
• Gene: HYCC1 / 84668
• HGNCID: 24587
• Length: 521
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 154/552 - (27%)
• Similarity: 262/552 - (47%)
• Gaps: 74/552 - (13%)

  Fly     4 LVRDWLADYQRIRGQPSEAEAFVVEHETD----PEIAEAIFTIFNERQRNETLVHDICQQLLAFY 64
            :|.:||::::.:      .|..:..:.|:    ..:..:::.:..|.|  ..|:..:|.||..||
Human     8 VVEEWLSEFKTL------PETSLPNYATNLKDKSSLVSSLYKVIQEPQ--SELLEPVCHQLFEFY 64

  Fly    65 RSPEQTLHKFPLQFIPVLLYTYLHSVAGGDKKAARGVETLLICIYNGEVSTEDGGQKVVAFRMPI 129
            ||.|:.|.:|.|||:|.|::.||...|..:..::..:|.||:.:||.|:..:.|..||::|.:|.
Human    65 RSGEEQLLQFTLQFLPELIWCYLAVSASRNVHSSGCIEALLLGVYNLEIVDKQGHTKVLSFTIPS 129

  Fly   130 LAQTSVYHE---VKNLPMTDLRRWEENCNREVKWGPHQRIESIHAQNRMRILTALLFCYNQQVSQ 191
            |::.|||||   :.::.:|:....:...::.|..|||.:.|.:.||||..:||.||.|||..::.
Human   130 LSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTY 194

  Fly   192 TQKSSLLHLCRVTSQLVNQGFTTKSGHGHRMSYGSDPATGVPFPKPSSPRIPLSAAFLIELVHAI 256
            ....||..||::.|::...|:..:    |...|           |..|.|||:|:.|:::::..|
Human   195 MPSVSLQSLCQICSRICVCGYPRQ----HVRKY-----------KGISSRIPVSSGFMVQMLTGI 244

  Fly   257 YFAMFNGFGTIAIQTLDDIHNRAIYEMYSEVILVTSAVRNSLHANPSGQPNDGPMGLSVALTPST 321
            |||.:||...:|.:.||||..||..|:|.|.:||.:|::.||...|.....:|...:.|.:||:
Human   245 YFAFYNGEWDLAQKALDDIIYRAQLELYPEPLLVANAIKASLPHGPMKSNKEGTRCIQVEITPT- 308

  Fly   322 TTVTTSVSKSMITNASF---RTKKLPDDIPIQVQDLTIQQAPQQLASVTEETEPGTKESPSTKES 383
               ::.:|::.:|:.|.   |.|:..:      .:||.|   ::|..::|..|.....:.|:...
Human   309 ---SSRISRNAVTSMSIRGHRWKRHGN------TELTGQ---EELMEISEVDEGFYSRAASSTSQ 361

  Fly   384 SGTRTSIMRPSMEGIKAQAHKALIAGFKKSKDKEKE------KDKEPPKPPQRKFDKHTQRNSLL 442
            ||...|....|.:....:.|:.  :|..|:..||||      ||....|..||...::.:..||.
Human   362 SGLSNSSHNCSNKPSIGKNHRR--SGGSKTGGKEKETTGESCKDHFARKQTQRAQSENLELLSLK 424

  Fly   443 QLQ-------AEPSSNSSAEQPPT----------GEVLPLQTLSLIN---ENGSNSFSVDSDLND 487
            :|.       .:|||:..|:...|          |..:|....|.:.   ...:|.||..|...:
Human   425 RLTLTTSQSLPKPSSHGLAKTAATVFSKSFEQVSGVTVPHNPSSAVGCGAGTDANRFSACSLQEE 489

  Fly   488 GVLGVSANTSLPPLSSTTNSVTSSDLITKSFD 519
            .::.||..|.||....:......|..||.|.|
Human   490 KLIYVSERTELPMKHQSGQQRPPSISITLSTD 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hyccin	NP_611256.1	Hyccin	20..346	CDD:462903	103/335 (31%)
HYCC1	NP_115970.2	Hyccin	22..330	CDD:462903	102/328 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..413		16/59 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..521		5/19 (26%)