Protein Alignment Hyccin and HYCC2

DIOPT Version :10

• Sequence 1: NP_611256.1
• Gene: Hyccin / 37019
• FlyBaseID: FBgn0034269
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_001308552.1
• Gene: HYCC2 / 285172
• HGNCID: 28593
• Length: 586
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 148/557 - (26%)
• Similarity: 255/557 - (45%)
• Gaps: 101/557 - (18%)

  Fly     4 LVRDWLADYQRIRGQPSEAEAFVVEHETDPEIAEAIFTIFNERQRNETLVHDICQQLLAFYRSPE 68
            :|.:||::::.:  ..::..::.........:..|::.:..:  .|..|:..:|.||...|||.|
Human     8 VVEEWLSEFKAL--PDTQITSYAATLHRKKTLVPALYKVIQD--SNNELLEPVCHQLFELYRSSE 68

  Fly    69 QTLHKFPLQFIPVLLYTYLHSVAGGDKKAARGVETLLICIYNGEVSTEDGGQKVVAFRMPILAQT 133
            ..|.:|.|||:|.|::.||......|:::...:|.||:.|||.|::.:||..||::|.:|.|::.
Human    69 VRLKRFTLQFLPELMWVYLRLTVSRDRQSNGCIEALLLGIYNLEIADKDGNNKVLSFTIPSLSKP 133

  Fly   134 SVYHE---VKNLPMTDLRRWEENCNREVKWGPHQRIESIHAQNRMRILTALLFCYNQQVSQTQKS 195
            |:|||   :.::.:|:....:.:..|.|....|.:.|:..||||..:|:.|:.|||..:.....|
Human   134 SIYHEPSTIGSMALTEGALCQHDLIRVVYSDLHPQRETFTAQNRFEVLSFLMLCYNSAIVYMPAS 198

  Fly   196 SLLHLCRVTSQLVNQGFTTKSGHGHRMSYGSDPATGVPFPKPSSPRIPLSAAFLIELVHAIYFAM 260
            |...|||:.|::...||..:    |...:           |....||.|...|:::|:..:|:||
Human   199 SYQSLCRMGSRVCVSGFPRQ----HEKHW-----------KELCGRIVLDPEFMVQLLTGVYYAM 248

  Fly   261 FNGFGTIAIQTLDDIHNRAIYEMYSEVILVTSAVRNSLHANPSGQPNDGPMGLSVALTPSTTTVT 325
            :||...:..:.||||..||..|::|:.:||.:|::|||..:......:|...|.|.:||:    .
Human   249 YNGQWDLGQEVLDDIIYRAQLELFSQPLLVANAMKNSLPFDAPDSTQEGQKVLKVEVTPT----V 309

  Fly   326 TSVSKSMITNASFR------------TKKLPDDIP---------------IQVQDLTIQQAPQ-- 361
            ..:|::.||.||.|            :.:....||               :|..::.:::.|:
Human   310 PRISRTAITTASIRRHRWRREDGFDFSNEADSSIPGSPIQHGSTDLGIKRVQEGEVLVRRTPEHG 374

  Fly   362 --QLASVTEETE-----PGTKESPSTKE-----SSGTRTSIM----RPSMEGIKAQAHKALIAGF 410
              :..|.|..||     .|.:||.:..:     |||...|..    :||....:....|  :|..
Human   375 SPEPNSATATTEGAEGVNGGEESVNLNDADEGFSSGASLSSQPIGTKPSSSSQRGSLRK--VATG 437

  Fly   411 KKSKDKEKE---KDKEPPKPPQRKFDKHTQRNSLLQLQAEPSSNSSAEQP-------PTGEVLP- 464
            :.:||||..   |..|.|:       ....|...:|...:.|.:|....|       |.|:|:|
Human   438 RSAKDKETASAIKSSESPR-------DSVVRKQYVQQPTDLSVDSVELTPMKKHLSLPAGQVVPK 495

  Fly   465 LQTLSLI---NENGSNSFSVDSDLNDGVLGVSANTSL 498
            :.:||||   :.:.|.||       |.|.|..|:||:
Human   496 INSLSLIRTASASSSKSF-------DYVNGSQASTSI 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hyccin	NP_611256.1	Hyccin	20..346	CDD:462903	97/340 (29%)
HYCC2	NP_001308552.1	Hyccin	22..330	CDD:462903	97/328 (30%)