DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34195 and ALKBH8

DIOPT Version :9

Sequence 1:	NP_001097360.1	Gene:	CG34195 / 37018	FlyBaseID:	FBgn0085224	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_001287939.2	Gene:	ALKBH8 / 91801	HGNCID:	25189	Length:	664	Species:	Homo sapiens

Alignment Length:	314	Identity:	67/314 - (21%)
Similarity:	103/314 - (32%)	Gaps:	102/314 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EPLEPDVITTQAKELSAVERQKLDEQNKRGLVPEYKANK-----------LEIDAQRNWDIFYKR 55
            |.|:..:||:...:|:.         :||||...:...|           |..|:||      |.
Human   306 ESLKSGIITSDVGDLTL---------SKRGLRTSFTFRKVRQTPCNCSYPLVCDSQR------KE 355

  Fly    56 NETRFFKDRHWTTREFQELLDQ--EEF--HEKRT--------------------LFEVGCGVGNL 96
            ....|.:.....:|..||.:.|  ||.  |...|                    :.::|||.|..
Human   356 TPPSFPESDKEASRLEQEYVHQVYEEIAGHFSSTRHTPWPHIVEFLKALPSGSIVADIGCGNGKY 420

  Fly    97 VFPLLEEQTSEEGCFSNSRFFFYACDFSPRAVEFVRSNPLYDPSQISAFQCDITTQQVHDHIPPS 161
            :           |.  |...:...||.|...|:..|..      |..||.||.....|..    .
Human   421 L-----------GI--NKELYMIGCDRSQNLVDICRER------QFQAFVCDALAVPVRS----G 462

  Fly   162 SVDICTLIFVLSAIH----PQKFKDVVQNLGKLLKPGGLLLFRDYGL---YDMAQLRFKPGNKIA 219
            |.|.|..|.|   ||    .::....:|.:.:||:|||..|...:.:   |:..:.::..||:
Human   463 SCDACISIAV---IHHFATAERRVAALQEIVRLLRPGGKALIYVWAMEQEYNKQKSKYLRGNR-- 522

  Fly   220 ENLYVRQDGTRSYFFSEEEVSKLFQENGFEVITNAYVHRRTLNLKEGV-DVPRI 272
                 ...|.:....|:..|.:...|           ..|.:..::.. .||||
Human   523 -----NSQGKKEEMNSDTSVQRSLVE-----------QMRDMGSRDSASSVPRI 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34195	NP_001097360.1	Methyltransf_12	88..>175	CDD:369778	22/86 (26%)
ALKBH8	NP_001287939.2	DUF1891	1..37	CDD:117570
		RRM_ALKBH8	42..122	CDD:409865
		2OG-FeII_Oxy	152..334	CDD:419693	9/36 (25%)
		Alpha-ketoglutarate binding. /evidence=ECO:0000269\|PubMed:22065580	227..229
		Methyltransf_25	410..497	CDD:404528	28/112 (25%)
		Methyltransferase domain	411..664		43/194 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..575		11/64 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910