DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34195 and METTL6

DIOPT Version :9

Sequence 1:	NP_001097360.1	Gene:	CG34195 / 37018	FlyBaseID:	FBgn0085224	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_689609.2	Gene:	METTL6 / 131965	HGNCID:	28343	Length:	284	Species:	Homo sapiens

Alignment Length:	274	Identity:	153/274 - (55%)
Similarity:	197/274 - (71%)	Gaps:	14/274 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QAKELSAVERQKLDEQNKRGLVPEYKANKLEIDAQRNWDIFYKRNETRFFKDRHWTTREFQELLD 76
            ||:.|::.|.:||  :..:.||.::|..|||.:||:|||:|||||.|.||||||||||||:||..
Human    10 QARILTSEEEEKL--KRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRS 72

  Fly    77 QEEFH-EKRTLFEVGCGVGNLVFPLLEEQTSEEGCFSNSRFFFYACDFSPRAVEFVRSNPLYDPS 140
            ..||. :|.|:.|.||||||.:||||||         :...|.|||||||||:|:|:.|||||..
Human    73 CREFEDQKLTMLEAGCGVGNCLFPLLEE---------DPNIFAYACDFSPRAIEYVKQNPLYDTE 128

  Fly   141 QISAFQCDITTQQVHDHIPPSSVDICTLIFVLSAIHPQKFKDVVQNLGKLLKPGGLLLFRDYGLY 205
            :...||||:|...:.||:||.|||:..|||||||:||.|...|:||:.|:||||..:||||||||
Human   129 RCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLY 193

  Fly   206 DMAQLRFKPGNKIAENLYVRQDGTRSYFFSEEEVSKLFQENGFEVITNAYVHRRTLNLKEGVDVP 270
            |.|.||||..:|:.||.||||||||||||:::.:::||.:.|:|.:.|.||.|.|:|.|||:.||
Human   194 DHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVP 258

  Fly   271 RIFLQGKFRR--KN 282
            |:|||.||.:  ||
Human   259 RVFLQSKFLKPPKN 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34195	NP_001097360.1	Methyltransf_12	88..>175	CDD:369778	48/86 (56%)
METTL6	NP_689609.2	Methyltransf_12	84..182	CDD:369778	58/106 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160176
Domainoid	1	1.000	74	1.000	Domainoid score	I9220
eggNOG	1	0.900	-	-		E1_KOG2361
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12069
Inparanoid	1	1.050	313	1.000	Inparanoid score	I2579
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51971
OrthoDB	1	1.010	-	-		D378076at33208
OrthoFinder	1	1.000	-	-		FOG0000942
OrthoInspector	1	1.000	-	-		oto89407
orthoMCL	1	0.900	-	-		OOG6_104549
Panther	1	1.100	-	-	LDO	PTHR22809
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1971
SonicParanoid	1	1.000	-	-		X3769
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800