DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snx16 and SNX21

DIOPT Version :9

Sequence 1:	NP_611252.1	Gene:	Snx16 / 37015	FlyBaseID:	FBgn0034265	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_219489.1	Gene:	SNX21 / 90203	HGNCID:	16154	Length:	373	Species:	Homo sapiens

Alignment Length:	290	Identity:	65/290 - (22%)
Similarity:	108/290 - (37%)	Gaps:	86/290 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 KLLGRKCH-----------SSPDLRQIGKYQNNSLLRSKSEGDVSLILASNSGAPLTVANAKSEV 121
            :||.|..|           :||:..|..  :::.|....:||     |:|.....|:..:|:.:
Human    13 RLLHRLRHALAGDGPGEAAASPEAEQFP--ESSELEDDDAEG-----LSSRLSGTLSFTSAEDD- 69

  Fly   122 CLQRISSHSYEQSPRTPINKSEM-LGGARSHRDLTQS-----SYGNQAGGHSV-DLESRSR---T 176
                   ...|..........:: ||...|..|..:|     .:|:|.....: |...:||   .
Human    70 -------EDDEDEDDEEAGPDQLPLGDGTSGEDAERSPPPDGQWGSQLLARQLQDFWKKSRNTLA 127

  Fly   177 PRRMSECSLGYSQSSSRHTGSNSMFASQMTLSSGSVV--PPVDPNAVLRVPIIGYEVMEERARFT 239
            |:|:                   :|    .::|.:||  ||                    :::.
Human   128 PQRL-------------------LF----EVTSANVVKDPP--------------------SKYV 149

  Fly   240 AYKLRVENPETNDYW--LVMRRYTDFVRLNSKLKQAF--PNLTLMLPRKKLFGDNFNAVFLDNRV 300
            .|.|.|..|...|..  .:.|||:||.||:..|::.|  |...:..|||:| ..||.|..:..|.
Human   150 LYTLAVIGPGPPDCQPAQISRRYSDFERLHRNLQRQFRGPMAAISFPRKRL-RRNFTAETIARRS 213

  Fly   301 QGLQIFVNSVMAKEELRKCKLVREFFCLDE 330
            :..:.|:..:.|..|||....:::||.|.|
Human   214 RAFEQFLGHLQAVPELRHAPDLQDFFVLPE 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx16	NP_611252.1	PX_SNX16	219..329	CDD:132809	30/113 (27%)
SNX21	NP_219489.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107		20/108 (19%)
		PX_SNX21	131..242	CDD:132834	36/154 (23%)
		TPR repeat	244..268	CDD:276809	65/290 (22%)
		TPR_12	247..312	CDD:290160
		TPR repeat	281..312	CDD:276809
		TPR repeat	326..353	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810