DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx16 and SNX14

DIOPT Version :9

Sequence 1:	NP_611252.1	Gene:	Snx16 / 37015	FlyBaseID:	FBgn0034265	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001337461.1	Gene:	SNX14 / 57231	HGNCID:	14977	Length:	967	Species:	Homo sapiens

Alignment Length:	451	Identity:	99/451 - (21%)
Similarity:	165/451 - (36%)	Gaps:	148/451 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 KKSLLKTGNSVCGLDKRSQFREQK-LLGRKCHSSPDLRQIGKYQ-----------NNSLLRSKSE 97
            |.|:||.        :..|.|||: ||.|..:.   |:|.|...           |:.:||.:..
Human   350 KPSVLKL--------ELKQIREQQDLLFRFMNF---LKQEGAVHVLQFCLTVEEFNDRILRPELS 403

  Fly    98 GDVSLILASN-------------------------------SGAPLTVANAKSEVCLQRISSH-- 129
            .|..|.|...                               .|..:.|...::..||.....|
Human   404 NDEMLSLHEELQKIYKTYCLDESIDKIRFDPFIVEEIQRIAEGPYIDVVKLQTMRCLFEAYEHVL 468

  Fly   130 SYEQSPRTPI--NKSE----MLGGARSHRDLTQSSYGNQAGGHSVDLESRSRTPRRMSECSLGYS 188
            |..::..||:  :..|    :|.||.|.   |::|..|:.   |:.|:....|.:|..  |.|.|
Human   469 SLLENVFTPMFCHSDEYFRQLLRGAESP---TRNSKLNRG---SLSLDDFRNTQKRGE--SFGIS 525

  Fly   189 QSSSRHTGSNSMFASQMTLSSGSVVP-----------------------PVD----PNA------ 220
            :..|:..|   :|.|  |...|:::|                       ||:    ||.
Human   526 RIGSKIKG---VFKS--TTMEGAMLPNYGVAEGEDDFIEEGIVVMEDDSPVEAVSTPNTPRNLAA 585

  Fly   221 -VLRVPIIGY------EVMEERARFTAYKLRVENPETN------DYWLVMRRYTDFVRLNSKLKQ 272
             .:.:|.:.:      |..|::.|...:.:.||..:..      ::|.|.|||.:|..|.|||.:
Human   586 WKISIPYVDFFEDPSSERKEKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTE 650

  Fly   273 ---AFPNLTLMLPRKKLFGDNFNAVFLDNRVQGLQIFVNSVMAKEELRKCKLVREFFCLDEPPSY 334
               |||:  ..||.|::.|.. |..||.::.:..|.::..::...||...:|:.:|.    .|:.
Human   651 FHGAFPD--AQLPSKRIIGPK-NYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFL----SPNG 708

  Fly   335 SESMEECRAIFEAQEETIEHLKLQIRNKNDLILSLQQKLREEMNEKEQ-LREAMKNMELNC 394
            .|:            :.::.:...: |...:|.|:..||   |.||.| |...:.|...:|
Human   709 GET------------QFLDKILPDV-NLGKIIKSVPGKL---MKEKGQHLEPFIMNFINSC 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx16	NP_611252.1	PX_SNX16	219..329	CDD:132809	32/131 (24%)
SNX14	NP_001337461.1	PXA	151..320	CDD:308031
		RGS_SNX14	361..487	CDD:188677	24/128 (19%)
		PX_SNX14	585..707	CDD:132787	31/128 (24%)
		Nexin_C	828..932	CDD:312222
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810