DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx16 and Rps6kc1

DIOPT Version :9

Sequence 1:	NP_611252.1	Gene:	Snx16 / 37015	FlyBaseID:	FBgn0034265	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_848890.3	Gene:	Rps6kc1 / 320119	MGIID:	2443419	Length:	1056	Species:	Mus musculus

Alignment Length:	437	Identity:	94/437 - (21%)
Similarity:	155/437 - (35%)	Gaps:	139/437 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LAAPARTSQATLFK--KASTAITSPKKSLLK--TGNSVC----GLDKRSQFRE-QKLLGRKCHSS 77
            |....||.|..:.|  :.|:..:..:|:::.  ..|.||    .:.:.|.|.. |:..|.|..|
Mouse   350 LVMDTRTEQTFILKGLRKSSECSRNRKTIIPRCVPNMVCLHTYIISEESVFLVLQRAEGGKLWS- 413

  Fly    78 PDLRQIGKYQNNSLLRSKSEGDVSLILASNSGAPLTVANAKSEVCLQRISS-----HSYEQSP-- 135
                .|.|:.|    ||..|.     |....|.|    :....||||:.|:     .|:|...
Mouse   414 ----YISKFLN----RSSQES-----LDIKEGRP----SMPPRVCLQQPSASPQGGSSFESRGSD 461

  Fly   136 ----------RTPINKSEMLGGARSHRDLTQSSYGNQAGGHSVDLESRSRTPRRMSECSLGYSQS 190
                      :|.:..|       |..|..|...|..:....:|..|.|.     .||:.||...
Mouse   462 TGSMLKALPLKTSLTPS-------SQDDSNQEDDGQPSSPKWLDSGSSSE-----DECTAGYLTL 514

  Fly   191 SSRHTGSNSMFASQMTLSSGSVVPP--------------------VDPNAVLRVPIIGYEVMEER 235
            .:.: |...|  ..::||..||:.|                    |.|:..||| ..|.|.:|
Mouse   515 CNEY-GQEKM--DLVSLSEESVMQPEGDKADTQAVSSPASLATGSVSPSTHLRV-FSGGEDLE-- 573

  Fly   236 ARFTAYKLRVENPETNDYWLVMRRY-TDFVRLNSKLKQAFPNLTLMLPRKKLFGDNFNAVFLDNR 299
                    .|.:|.|::.....:.. .:|.|::||...:           :|.|.:|.
Mouse   574 --------AVSSPPTSESLSRSKNSPMEFFRIDSKDSTS-----------ELLGLDFG------- 612

  Fly   300 VQGLQIFVNSVMAKEELRKCK--LVREFFCLDEPPSYSESME--ECRAIFEAQEETIEHLKLQIR 360
                          |:|...|  .::..|.|::..|.|:|::  |.:...|||:..       .|
Mouse   613 --------------EKLHSLKPEPLKALFTLEDGDSPSQSLDPGESKRESEAQDSV-------SR 656

  Fly   361 NKNDL--ILSLQQKLREEMNEKEQLR-EAMKNM--ELNCSHCSSASD 402
            ..:|.  ::|.::...|.::..|:.| :.:.|:  ||..:..:||.|
Mouse   657 GSDDSVPVISFKEAAAEAISGAEEGRPDLLVNLPGELQPTKEASAMD 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx16	NP_611252.1	PX_SNX16	219..329	CDD:132809	20/112 (18%)
Rps6kc1	NP_848890.3	PX_RPK118_like	11..128	CDD:132820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..223
		MIT_SNX15	237..309	CDD:239140
		PKc_like	334..>427	CDD:304357	22/90 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..504		18/93 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..588		15/69 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	628..662		10/40 (25%)
		S_TKc	<864..1046	CDD:214567
		STKc_RPK118_like	<869..1046	CDD:270728
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900