DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and SH3GL1

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_003016.1	Gene:	SH3GL1 / 6455	HGNCID:	10830	Length:	368	Species:	Homo sapiens

Alignment Length:	204	Identity:	51/204 - (25%)
Similarity:	79/204 - (38%)	Gaps:	31/204 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 EKEHGLSPDSKM-VVLHDFTPCVDDELEVKRGQLVNILYRENDWVYVIGQDSRQEGFI--PFSYC 112
            :|..|..||.:: ..|..|    ::..||....:.|:|  |.|    |.|.|:....:  ...|.
Human   172 KKRQGKIPDEELRQALEKF----EESKEVAETSMHNLL--ETD----IEQVSQLSALVDAQLDYH 226

  Fly   113 APCNTQLADLAVKKKLPREQCPEQPIEENIPLLGTDNKLDVLCDETLNPG-------------SA 164
            ......|.:||.|.|....:...:|..|..|  ......|:...|..|.|             |.
Human   227 RQAVQILDELAEKLKRRMREASSRPKREYKP--KPREPFDLGEPEQSNGGFPCTTAPKIAASSSF 289

  Fly   165 NSIENTLLVEPECTPFVKEPSGRCIVLYTFIARDENDLSVERGEFVTVLNREDPDWFWIMRSDGQ 229
            .|.:..:.......|.:.:||  |..||.|...::.:|....|:.:|:.|:.|.:|:..| .|||
Human   290 RSSDKPIRTPSRSMPPLDQPS--CKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGM-LDGQ 351

  Fly   230 EGFVPASFI 238
            .||.|.|::
Human   352 SGFFPLSYV 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	11/52 (21%)
		SH3	184..238	CDD:214620	20/53 (38%)
		SH3	293..346	CDD:212690
SH3GL1	NP_003016.1	Membrane-binding amphipathic helix. /evidence=ECO:0000250	1..21
		BAR_Endophilin_A	25..247	CDD:153276	21/84 (25%)
		Required for dimerization upon membrane association. /evidence=ECO:0000250	60..87
		Interaction with ARC. /evidence=ECO:0000250	218..254		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..308		10/65 (15%)
		SH3_Endophilin_A	309..363	CDD:212737	20/55 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149741
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840