DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and SH3RF1

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_065921.2	Gene:	SH3RF1 / 57630	HGNCID:	17650	Length:	888	Species:	Homo sapiens

Alignment Length:	107	Identity:	26/107 - (24%)
Similarity:	49/107 - (45%)	Gaps:	13/107 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 AVGVLGMGRITGSSSIETLVRVGIEKEHGLSPDSK---MVVLHDFTPCVDDELEVKRGQLVNILY 88
            |....|||....:.|.:.:..        |.|.::   .|.::.:||..:||||:::|::..:..
Human   420 AAAAAGMGPRPMAGSTDQIAH--------LRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFE 476

  Fly    89 R-ENDWVYVIGQDSRQEGFIPFSYCAPCNTQLADLAVKKKLP 129
            | ::.|.......:.:.|..|.:|.||. |:....|.:.|:|
Human   477 RCQDGWFKGTSMHTSKIGVFPGNYVAPV-TRAVTNASQAKVP 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	12/53 (23%)
		SH3	184..238	CDD:214620
		SH3	293..346	CDD:212690
SH3RF1	NP_065921.2	RING	11..56	CDD:238093
		SH3	137..190	CDD:302595
		SH3_SH3RF1_2	200..254	CDD:212863
		SH3_SH3RF1_3	449..503	CDD:212859	13/53 (25%)
		SH3_SH3RF_C	833..887	CDD:212719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149740
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930