DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and SH3GLB2

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_006717251.1	Gene:	SH3GLB2 / 56904	HGNCID:	10834	Length:	428	Species:	Homo sapiens

Alignment Length:	297	Identity:	54/297 - (18%)
Similarity:	91/297 - (30%)	Gaps:	107/297 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CPVRMRRDKKKATNASIERD--------------LPAVGVLGMG-RITGSSS------------- 41
            |..|:::.|.....|:.|.|              |.|....|.| |:..|||
Human   172 CKARLKKAKAAEAKATCEGDTVPDFQETRPRNYILSASASAGTGSRVQLSSSPLPCWPLLLPSPQ 236

  Fly    42 -------------------------IETLVRVGIEKEHGLSPDSKMVVLHDF--------TPCVD 73
                                     :..|:..||...|    .:.:..||:|        ..|..
Human   237 LWNDEVDKAEQELRVAQTEFDRQAEVTRLLLEGISSTH----VNHLRCLHEFVKSQTTYYAQCYR 297

  Fly    74 DELEVKRGQLVNILYRENDWVYVIGQDSRQEGFIPFSYCAPCNTQLADLAVKKKLPREQCPEQPI 138
            ..|:::: ||                .|.|....|.::..  .|:.|...:....|.......|:
Human   298 HMLDLQK-QL----------------GSSQGAIFPGTFVG--TTEPASPPLSSTSPTTAAATMPV 343

  Fly   139 EENIPLLGTDNKLDVLCDETLNPGSANSIENTLLVEPECTPFVKEPSGRCIVLYTFIARDENDLS 203
            ..::..|....:..:..:|...|.|.                    :.:..|||.:.|.|.::|:
Human   344 VPSVASLAPPGEASLCLEEVAPPASG--------------------TRKARVLYDYEAADSSELA 388

  Fly   204 VERGEFVTV--LNREDPDWFWIMRSDGQEGFVPASFI 238
            :...|.:||  |...||||. |.....::|.||.:::
Human   389 LLADELITVYSLPGMDPDWL-IGERGNKKGKVPVTYL 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	10/57 (18%)
		SH3	184..238	CDD:214620	18/55 (33%)
		SH3	293..346	CDD:212690
SH3GLB2	XP_006717251.1	BAR_Endophilin_B2	21..306	CDD:153301	23/138 (17%)
SH3GLB2	XP_006717251.1	SH3_Endophilin_B2	372..426	CDD:212877	18/54 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149739
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930