DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and sh3rf1

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001038952.2	Gene:	sh3rf1 / 556523	ZFINID:	ZDB-GENE-030131-6288	Length:	880	Species:	Danio rerio

Alignment Length:	315	Identity:	72/315 - (22%)
Similarity:	105/315 - (33%)	Gaps:	83/315 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ATNASIERDLPAVGVLGMGRITGSSSIETLVRV-GIEKEHGLSPDSKMVVLHDFT-------PCV 72
            |....||.|.|:.|  |.....|.||..:..:. |.:|..|...:||.  .|.||       ||:
Zfish   270 AARQLIELDKPSEG--GGDSSEGPSSSSSGPQANGSQKAPGEKKNSKK--RHSFTSLTMSHKPCL 330

  Fly    73 -----DDELEVKRGQLVNILYRENDWVYV-IGQDSR-------------QEGFI----PFS---- 110
                 ...:|:....|::   ..|..... ||:.|.             ..|.|    |.|
Zfish   331 APPPQRHSMEISGPVLIS---SSNPTAAARIGELSGGLSSSAPSQVHICTTGLIVTPPPSSPVTT 392

  Fly   111 ---YCAPCNTQLADLAVKKKLPREQCPEQPIEENIPLLGTDNKLDVLCDETLNPGSANSIENTLL 172
               :..|..|..|.:.|....|.   |..|.:....::|.         ..||.|...|
Zfish   393 ATVFTFPPETSYASIPVDALPPP---PPPPPQSQSSVVGA---------AALNAGQRPS------ 439

  Fly   173 VEPECTPFVKEPSGR-----CIVLYTFIARDENDLSVERGEFVTVLNREDPDWF-WIMRSDGQEG 231
                  |...:.|||     .:.::.:..|.|::|.:.:||...||.|....|| ......|:.|
Zfish   440 ------PAAGDQSGRQRPTVYVAMFPYSPRKEDELELRKGEMFLVLERCQDGWFKGTSMHTGKIG 498

  Fly   232 FVPASFIYPAD-SVRVLQQQKATLNAMETILQQGQQGQQSQQQQQPQLGLGTDDL 285
            ..|.:::.|.. :|....|.|..|    |:..|..:|...   ..|...||:.||
Zfish   499 VFPGNYMSPVSRTVSGSSQPKVPL----TLCSQAGRGVTI---VSPSSALGSMDL 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	16/86 (19%)
		SH3	184..238	CDD:214620	16/59 (27%)
		SH3	293..346	CDD:212690
sh3rf1	NP_001038952.2	RING	24..69	CDD:238093
		SH3_SH3RF1_1	148..201	CDD:212860
		SH3_SH3RF1_2	211..265	CDD:212863
		SH3_SH3RF1_3	453..507	CDD:212859	13/53 (25%)
		SH3_SH3RF_C	825..879	CDD:212719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583880
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930