DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and NPHP1

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_006712614.1	Gene:	NPHP1 / 4867	HGNCID:	7905	Length:	768	Species:	Homo sapiens

Alignment Length:	268	Identity:	60/268 - (22%)
Similarity:	108/268 - (40%)	Gaps:	64/268 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 EKE----HGLSPDSKMVVLHDFTPCVDDELEVKRGQLVNILYREND--WVYVIGQDSR-QEGFIP 108
            |||    |..|...:.:.:.|||.....:|..|:|:::.::.::.|  |   |.:|:: .||.:|
Human   142 EKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWW---IAKDAKGNEGLVP 203

  Fly   109 FSYCAPCNTQLADLAVKKKLPREQCPEQPIEENIPLLGTDNKLDVLCDETLNPGSANSIENTLLV 173
            .:|..|.:             .|:..::..||     |::..::.: |||     |:..|.....
Human   204 RTYLEPYS-------------EEEEGQESSEE-----GSEEDVEAV-DET-----ADGAEVKQRT 244

  Fly   174 EPECTPF---VKEPSGRCIV-----LYTFIARDENDLSVERGEFVTVLNREDPDW-FWIMRSDGQ 229
            :|..:..   :.|....|:|     .|..:      |...|.|.|...|..:..: .|.::|.|:
Human   245 DPHWSAVQKAISEAGIFCLVNHVSFCYLIV------LMRNRMETVEDTNGSETGFRAWNVQSRGR 303

  Fly   230 EGFVPASFIYPADSVRVLQQQKATLNAM------ETILQQGQQGQQSQQQQ--QPQL---GLGTD 283
            ...|....:...::|.||    .|:.|:      .|:.|..::|.|.:...  ||:|   .|...
Human   304 IFLVSKPVLQQINTVDVL----TTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQLAFR 364

  Fly   284 DLRYHGTE 291
            ||.:..||
Human   365 DLMWDATE 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	13/52 (25%)
		SH3	184..238	CDD:214620	12/59 (20%)
		SH3	293..346	CDD:212690
NPHP1	XP_006712614.1	SH3_Nephrocystin	156..209	CDD:212704	14/55 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100