DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and NCF4

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_038202.2	Gene:	NCF4 / 4689	HGNCID:	7662	Length:	348	Species:	Homo sapiens

Alignment Length:	224	Identity:	49/224 - (21%)
Similarity:	86/224 - (38%)	Gaps:	49/224 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 IEKEHGLSPDSKMVVLHDFTPCVDDELEVK-RGQLVNILYRENDWVYVIGQDSRQEGFIPFSYCA 113
            ||::.|.:.....|:            ||| :|....::||.....:.: |...:|.|.|.|..:
Human    29 IEEKRGFTSHFVFVI------------EVKTKGGSKYLIYRRYRQFHAL-QSKLEERFGPDSKSS 80

  Fly   114 PCNTQLADLAVKKKLPREQCPEQPIEENIPLLGTDNK------LDVLCDETL------NPGSANS 166
            .....|..|..|..:..:|   :..|..||.|....|      :.||.||.:      :|..:..
Human    81 ALACTLPTLPAKVYVGVKQ---EIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQ 142

  Fly   167 IENTL-----------LVEPECTPFVKEPSGRCIVLYTFIARDENDLSVERGEFVTVLNREDPDW 220
            :...|           .|.|:.....:..:.|...|:.|....:.:|:.:.|:.:.:|:|.:.||
Human   143 VPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLLSRINKDW 207

  Fly   221 FWIMRSDGQEGFV-PASFIYPADSVRVLQ 248
            .        ||.| .|:.|:|...|::|:
Human   208 L--------EGTVRGATGIFPLSFVKILK 228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	11/50 (22%)
		SH3	184..238	CDD:214620	13/54 (24%)
		SH3	293..346	CDD:212690
NCF4	NP_038202.2	PX_p40phox	19..141	CDD:132792	29/127 (23%)
		Phosphatidylinositol 3-phosphate binding	58..60		0/1 (0%)
		Phosphatidylinositol 3-phosphate binding	92..94		1/1 (100%)
		SH3_p40phox	174..227	CDD:212802	16/60 (27%)
		PB1	238..>258	CDD:295447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149743
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930