DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and Sorbs3

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001005762.1	Gene:	Sorbs3 / 282843	RGDID:	628900	Length:	733	Species:	Rattus norvegicus

Alignment Length:	357	Identity:	74/357 - (20%)
Similarity:	122/357 - (34%)	Gaps:	116/357 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EHGLSPDSK-------MVVLHDFTPCVDDELEVKRGQLVNILYRENDWVYVIGQDSRQEGFIPFS 110
            |.|.||..|       ..:..||......||.:::|.:|.| ::|.|..::.|:...:.|..|.:
  Rat   432 ERGSSPARKEEKKRKAARLKFDFQAQSPKELTLQKGDIVYI-HKEVDKNWLEGEHHGRLGIFPAN 495

  Fly   111 YCAPCNTQLADLAVKKKLPREQCPEQPIEENIPLLGTDNKLDVLCDETLNPGSANSIENTLLVEP 175
            |.             :.||.::.| :||:                     |.:...:|
  Rat   496 YV-------------EVLPADEIP-KPIK---------------------PPTYQVLE------- 518

  Fly   176 ECTPFVKEPSGRCIVLYTFIARDENDLSVERGEFVTVLNREDPDWF-WIMRSDGQEGFVPASFIY 239
                     .|..:..|||....:.:||..:||.:.::.:.:..|: ..:...|::|..|||::.
  Rat   519 ---------YGDAVAQYTFKGDLDVELSFRKGERICLIRKVNEHWYEGRITGTGRQGIFPASYVQ 574

  Fly   240 PADSVRVL----QQQKATLNAMETILQQGQQGQQS---------------------------QQQ 273
            .....|:.    ..|..|...:.|....|...|.|                           :.:
  Rat   575 INREPRLRLCDDSPQLPTSPHLTTTAHLGSHSQPSSIPVDPTDWGGRTSPRRSAFPFPITLQEPR 639

  Fly   274 QQPQ------------------LGLGTDDL---RYHGTELVMLYDYKAQAPDDLYLSVRRGDWIY 317
            .|||                  ..||:..|   ..|.|....:|.|:.|..|:|.|  |.||.:
  Rat   640 SQPQSLSTPGPTLSHPRGTSHPTNLGSSSLNTTEIHWTPYRAMYQYRPQNEDELEL--REGDRV- 701

  Fly   318 ADLTNQTVDGWLWAYAPKTRKYGFIPKAYARP 349
             |:..|..|||....:.:|:|:|..|..|..|
  Rat   702 -DVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	13/56 (23%)
		SH3	184..238	CDD:214620	14/54 (26%)
		SH3	293..346	CDD:212690	18/52 (35%)
Sorbs3	NP_001005762.1	Sorb	165..214	CDD:128735
		PTZ00449	<305..>444	CDD:185628	5/11 (45%)
		SH3_Vinexin_1	446..500	CDD:212854	13/67 (19%)
		SH3_Vinexin_2	520..575	CDD:212857	14/54 (26%)
		SH3_Vinexin_3	676..733	CDD:212851	21/61 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343643
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840