DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and Sh3d19

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_006501609.3	Gene:	Sh3d19 / 27059	MGIID:	1350923	Length:	1211	Species:	Mus musculus

Alignment Length:	387	Identity:	85/387 - (21%)
Similarity:	138/387 - (35%)	Gaps:	131/387 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GMGRITGSSSIETLVRVGIEKEHGLSPDS------------KMVVLHDFTPCVDDELEVKRGQLV 84
            |.||:..|..  .:|....|:..|...||            ..|.||||.....|:|.:..|::|
Mouse   881 GTGRVHPSQM--KIVTPLDERPRGRPNDSGHSQKPVDSGAPHAVALHDFPAEQADDLSLTSGEIV 943

  Fly    85 NIL-------YREN----------DWVYVI-----GQDSRQEGFIPFSYCAPCNTQLADLAVKKK 127
            .:|       ||..          ::|.||     |:..::|.|  .|:||             |
Mouse   944 YLLEKIDAEWYRGKCRNQTGVFPANYVKVIVDIPEGRSGKRESF--SSHCA-------------K 993

  Fly   128 LPR---------EQCPEQPIEENIPLLGTD--------------------NKLDVLCDETLNPGS 163
            .||         :|..|....|...::.|:                    |.::::.|   :|.|
Mouse   994 GPRCVARFEYIGDQKDELSFSEGEVIILTEYVNEEWGRGEIRDRSGIFPLNFVELVGD---HPTS 1055

  Fly   164 ANSIENTLL------VEPECTPFVKEPSGR-CIVLYTFIARDENDLSVERGEFVTVLNREDPDWF 221
            ..:|.:|.:      .:|........|.|. |..|::|.|....||..:||:.:.:|.|.|.||:
Mouse  1056 GANILSTKVPPKTKNEDPGSNSQDSSPPGEWCKALHSFTAETSEDLPFKRGDRILILERLDSDWY 1120

  Fly   222 WIMRSDGQEGFVPASFIYPADSVRVLQQQKATLNAMETILQQGQQGQQSQQQQQPQLGLGTDDLR 286
             ..|...:||..||.|:.|..:     :.|...:|:                  |:
Mouse  1121 -RGRLHDREGIFPAVFVQPCPA-----EAKGVASAI------------------PK--------- 1152

  Fly   287 YHGTELVMLYDYKAQAPDDLYLSVRRGDWIYADLTNQTVDGWLWAYAPKTRKYGFIPKAYAR 348
              |.::..|||:..:..|:  ||.:.|| :..:|  :.:|. .|.......:.|..||.|.:
Mouse  1153 --GRKVKALYDFLGENEDE--LSFKAGD-VITEL--EPIDD-AWMRGELMGRAGMFPKNYVQ 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	18/71 (25%)
		SH3	184..238	CDD:214620	20/54 (37%)
		SH3	293..346	CDD:212690	14/52 (27%)
Sh3d19	XP_006501609.3	PHA03247	<50..375	CDD:223021
		PTZ00449	<245..705	CDD:185628
		SH3_Eve1_1	840..889	CDD:212748	3/7 (43%)
		SH3	920..971	CDD:388381	12/50 (24%)
		SH3_Eve1_3	996..1046	CDD:212750	6/49 (12%)
		SH3	1086..1135	CDD:388381	18/49 (37%)
		SH3	1155..1204	CDD:388381	14/54 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839796
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930