DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and Sh3rf3

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_766376.2	Gene:	Sh3rf3 / 237353	MGIID:	2444637	Length:	878	Species:	Mus musculus

Alignment Length:	254	Identity:	54/254 - (21%)
Similarity:	99/254 - (38%)	Gaps:	48/254 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AFLCPVRMRRDKKKATNASIERDLPAVGVLGMGRITGSSSIETLVRVGIEKEHGLSPDSKMVVLH 66
            |.:||    |.....|:|:.....|.|....:....|.:.|..|....:... |..||.|
Mouse   653 AQMCP----RPAIPFTSAASAITPPNVSAANLSGEVGGTPISGLSTPSLINT-GFKPDDK----- 707

  Fly    67 DFTPCVDDELEVKRGQLVNILYRENDWVYVIGQDSRQEGFIPFSYCAPCNTQLA-DLAVKKKLPR 130
                  .:|.:.|:..|:.:|         .|..::::...|.|.....:.|.| |.:::..:..
Mouse   708 ------KNEKKEKKSGLLKLL---------AGASTKKKSRSPPSVSPTHDPQSAMDTSLQGAMGP 757

  Fly   131 EQCP--------EQPIEENI-------PLLGTDNKLDVLCDETLNPGSANSIENTLLVEPECTPF 180
            |..|        ..|||..:       ||......||:  :.:|:| |..:..:...:.||..|.
Mouse   758 EVSPLTVHGRAGSCPIESEMQGAIGLEPLHRKAGSLDL--NFSLSP-SRQATLSMASIRPEPKPL 819

  Fly   181 VKEPSGRCIVLYTFIARDENDLSVERGEFVTVLNREDPDWF-WIMRSDGQEGFVPASFI 238
            .:|   |..|:.::..:.|.::.::.|:.|.|..:.:..|| ..::.:|:.|..|.||:
Mouse   820 PRE---RYRVVVSYPPQSEAEIELKEGDIVFVHKKHEDGWFKGTLQRNGRTGLFPGSFV 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	7/49 (14%)
		SH3	184..238	CDD:214620	12/54 (22%)
		SH3	293..346	CDD:212690
Sh3rf3	NP_766376.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..40
		RING	51..93	CDD:238093
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..145
		SH3	190..243	CDD:302595
		SH3	253..307	CDD:302595
		Interaction with RAC1. /evidence=ECO:0000250\|UniProtKB:Q8TEJ3	364..433
		SH3_SH3RF3_3	461..517	CDD:212858
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..659		3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..758		16/90 (18%)
		SH3_SH3RF_C	823..877	CDD:212719	13/53 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839802
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840