Protein Alignment Dlish and Trio

DIOPT Version :10

• Sequence 1: NP_611251.2
• Gene: Dlish / 37014
• FlyBaseID: FBgn0034264
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_001074771.1
• Gene: Trio / 223435
• MGIID: 1927230
• Length: 3103
• Species: Mus musculus
• Alignment Length: 222
• Identity: 53/222 - (23%)
• Similarity: 92/222 - (41%)
• Gaps: 44/222 - (19%)

  Fly    53 EHGLSPDSKMVVLHDFTPCVDDELEVKRGQLVNILYRENDWVYVIGQDSRQEGFIPF--SYCAPC 115
            ||......|..:....||..|:::.:|...:.|    :.||:..| ::..||..:..  :...|.
Mouse  1546 EHVEGDPCKFALWVGRTPTSDNKIVLKASSIEN----KQDWIKHI-REVIQERTVHLRGALKEPI 1605

  Fly   116 NTQLADLAVKKKLPREQCPEQPIEENIPLLGTDNKLDVLCDETLNPG----SANSIENTLLVEPE 176
            :......|.::|..|:              |.|  ||...|.:..|.    ::.:.:|||..:
Mouse  1606 HIPKTAPAARQKGRRD--------------GED--LDSQGDGSSQPDTISIASRTSQNTLDSD-- 1652

  Fly   177 CTPFVKEPSGRC---IVLYTFIARDENDLSVERGEFVTVLNR--EDPDWFWIM---RSDGQEGFV 233
                  :.||.|   :|::.|.|.:.|:|::.||:.|.||.|  :.|||..:.   ||...||.|
Mouse  1653 ------KLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGLV 1711

  Fly   234 PASFIYPADSVRVLQQQKATLNAMETI 260
            |...:..|.| |...:.:...|..:::
Mouse  1712 PCGSLCIAHS-RSSMEMEGIFNHKDSL 1737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	11/51 (22%)
		SH3	184..238	CDD:214620	23/61 (38%)
		SH3	293..346	CDD:212690
Trio	NP_001074771.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		SEC14	69..204	CDD:214706
		Spectrin 1	218..338
		SPEC	220..445	CDD:238103
		Spectrin 2	340..446
		SPEC	341..566	CDD:238103
		Spectrin 3	566..672
		SPEC	567..783	CDD:238103
		Spectrin 4	673..784
		SPEC	787..1014	CDD:238103
		Spectrin 5	907..1012
		SPEC	908..1137	CDD:238103
		Spectrin 6	1138..1244
		SPEC	1143..1243	CDD:197544
		RhoGEF	1295..1465	CDD:238091
		PH1_Kalirin_Trio_like	1472..1594	CDD:270060	13/52 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1601..1651		13/65 (20%)
		SH3_Kalirin_1	1659..1718	CDD:212786	20/58 (34%)
		SH3-RhoG_link	1715..1972	CDD:465196	4/24 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1781..1906
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1927..1957
		RhoGEF	1970..2143	CDD:238091
		PH2_Kalirin_Trio_p63RhoGEF	2148..2286	CDD:270061
		SH3_Kalirin_2	2559..2617	CDD:212787
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2643..2666
		I-set	2689..2780	CDD:400151
		Ig strand B	2706..2710	CDD:409570
		Ig strand C	2719..2730	CDD:409570
		Ig strand E	2746..2750	CDD:409570
		Ig strand F	2760..2765	CDD:409570
		Ig strand G	2773..2776	CDD:409570
		STKc_Trio_C	2792..3054	CDD:271015