DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and Sorbs3

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_035496.1	Gene:	Sorbs3 / 20410	MGIID:	700013	Length:	733	Species:	Mus musculus

Alignment Length:	359	Identity:	73/359 - (20%)
Similarity:	124/359 - (34%)	Gaps:	121/359 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EHGLSPDSK-------MVVLHDFTPCVDDELEVKRGQLVNILYRENDWVYVIGQDSRQEGFIPFS 110
            |.|.||..|       ..:..||......||.:::|.:|.| ::|.|..::.|:...:.|..|.:
Mouse   433 ERGSSPSRKEEKKRKAARLKFDFQAQSPKELSLQKGDIVYI-HKEVDKNWLEGEHHGRLGIFPAN 496

  Fly   111 YCAPCNTQLADLAVKKKLPREQCPEQPIEENIPLLGTDNKLDVLCDETLNPGSANSIENTLLVEP 175
            |.             :.||.::.| :||:                     |.:...:|
Mouse   497 YV-------------EVLPADEIP-KPIK---------------------PPTYQVLE------- 519

  Fly   176 ECTPFVKEPSGRCIVLYTFIARDENDLSVERGEFVTVLNREDPDWF-WIMRSDGQEGFVPASFIY 239
                     .|..:..|||....|.:||..:||.:.::.:.:..|: ..:...|::|..|||::.
Mouse   520 ---------YGDAVAQYTFKGDLEVELSFRKGERICLIRKVNEHWYEGRITGTGRQGIFPASYVQ 575

  Fly   240 ----------------------------------------PAD-----SVR--------VLQQQK 251
                                                    |.|     |.|        .||:.:
Mouse   576 INREPRLRLCDDGPQLPASPNPTTTAHLSSHSHPSSIPVDPTDWGGRTSPRRSAFPFPITLQEPR 640

  Fly   252 ATLNAMETILQQGQQGQQSQQQQQP-QLGLGTDDLRYHGTELVMLYDYKAQAPDDLYLSVRRGDW 315
            :...::.|   .|......:...:| .||..:.:...|.|....:|.|:.|..|:|.|  |.||.
Mouse   641 SQTQSLNT---PGPTLSHPRATSRPINLGPSSPNTEIHWTPYRAMYQYRPQNEDELEL--REGDR 700

  Fly   316 IYADLTNQTVDGWLWAYAPKTRKYGFIPKAYARP 349
            :  |:..|..|||....:.:|:|:|..|..|..|
Mouse   701 V--DVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	13/56 (23%)
		SH3	184..238	CDD:214620	15/54 (28%)
		SH3	293..346	CDD:212690	18/52 (35%)
Sorbs3	NP_035496.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..165
		Sorb	165..214	CDD:128735
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..285
		PTZ00449	<306..>445	CDD:185628	5/11 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..448		5/14 (36%)
		Binds to vinculin	444..579		35/186 (19%)
		SH3_Vinexin_1	447..501	CDD:212854	13/67 (19%)
		SH3_Vinexin_2	521..576	CDD:212857	15/54 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..672		11/90 (12%)
		Binds to SOS. /evidence=ECO:0000250	674..733		22/63 (35%)
		SH3_Vinexin_3	676..733	CDD:212851	21/61 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840