Protein Alignment Dlish and Sh3gl1

DIOPT Version :10

• Sequence 1: NP_611251.2
• Gene: Dlish / 37014
• FlyBaseID: FBgn0034264
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_038692.1
• Gene: Sh3gl1 / 20405
• MGIID: 700010
• Length: 368
• Species: Mus musculus
• Alignment Length: 204
• Identity: 51/204 - (25%)
• Similarity: 81/204 - (39%)
• Gaps: 31/204 - (15%)

  Fly    51 EKEHGLSPDSKM-VVLHDFTPCVDDELEVKRGQLVNILYRENDWVYVIGQDSRQEGFI--PFSYC 112
            :|..|..||.:: ..|..|    ::..||....:.|:|  |.|    |.|.|:....:  ...|.
Mouse   172 KKRQGKIPDEELRQALEKF----EESKEVAETSMHNLL--ETD----IEQVSQLSALVDAQLDYH 226

  Fly   113 APCNTQLADLAVKKKLPREQCPEQPIEENIPLLGTDNKLDVLCDETLNPG-------------SA 164
            ......|.:||.|.|....:...:|..|..|......:|..|  |..|.|             |.
Mouse   227 RQAVQILEELADKLKRRVREASSRPKREFKPRPREPFELGEL--EQPNGGFPCAPAPKITASSSF 289

  Fly   165 NSIENTLLVEPECTPFVKEPSGRCIVLYTFIARDENDLSVERGEFVTVLNREDPDWFWIMRSDGQ 229
            .|.:..:.:..:..|.:.:||  |..||.|...::.:|....|:.:|:.|:.|.:|:..| ..||
Mouse   290 RSSDKPIRMPSKSMPPLDQPS--CKALYDFEPENDGELGFREGDLITLTNQIDENWYEGM-LHGQ 351

  Fly   230 EGFVPASFI 238
            .||.|.|::
Mouse   352 SGFFPLSYV 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	11/52 (21%)
		SH3	184..238	CDD:214620	19/53 (36%)
		SH3	293..346	CDD:212690
Sh3gl1	NP_038692.1	Membrane-binding amphipathic helix. /evidence=ECO:0000250	1..21
		BAR_Endophilin_A	25..247	CDD:153276	21/84 (25%)
		Required for dimerization upon membrane association. /evidence=ECO:0000250	60..87
		Interaction with ARC. /evidence=ECO:0000250	218..254		7/35 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	244..307		11/64 (17%)
		SH3_Endophilin_A	309..363	CDD:212737	19/55 (35%)