DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and Sh3gl1

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_038692.1	Gene:	Sh3gl1 / 20405	MGIID:	700010	Length:	368	Species:	Mus musculus

Alignment Length:	204	Identity:	51/204 - (25%)
Similarity:	81/204 - (39%)	Gaps:	31/204 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 EKEHGLSPDSKM-VVLHDFTPCVDDELEVKRGQLVNILYRENDWVYVIGQDSRQEGFI--PFSYC 112
            :|..|..||.:: ..|..|    ::..||....:.|:|  |.|    |.|.|:....:  ...|.
Mouse   172 KKRQGKIPDEELRQALEKF----EESKEVAETSMHNLL--ETD----IEQVSQLSALVDAQLDYH 226

  Fly   113 APCNTQLADLAVKKKLPREQCPEQPIEENIPLLGTDNKLDVLCDETLNPG-------------SA 164
            ......|.:||.|.|....:...:|..|..|......:|..|  |..|.|             |.
Mouse   227 RQAVQILEELADKLKRRVREASSRPKREFKPRPREPFELGEL--EQPNGGFPCAPAPKITASSSF 289

  Fly   165 NSIENTLLVEPECTPFVKEPSGRCIVLYTFIARDENDLSVERGEFVTVLNREDPDWFWIMRSDGQ 229
            .|.:..:.:..:..|.:.:||  |..||.|...::.:|....|:.:|:.|:.|.:|:..| ..||
Mouse   290 RSSDKPIRMPSKSMPPLDQPS--CKALYDFEPENDGELGFREGDLITLTNQIDENWYEGM-LHGQ 351

  Fly   230 EGFVPASFI 238
            .||.|.|::
Mouse   352 SGFFPLSYV 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	11/52 (21%)
		SH3	184..238	CDD:214620	19/53 (36%)
		SH3	293..346	CDD:212690
Sh3gl1	NP_038692.1	Membrane-binding amphipathic helix. /evidence=ECO:0000250	1..21
		BAR_Endophilin_A	25..247	CDD:153276	21/84 (25%)
		Required for dimerization upon membrane association. /evidence=ECO:0000250	60..87
		Interaction with ARC. /evidence=ECO:0000250	218..254		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..307		11/64 (17%)
		SH3_Endophilin_A	309..363	CDD:212737	19/55 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839793
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930