DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and Sh3gl2

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_062408.2	Gene:	Sh3gl2 / 20404	MGIID:	700009	Length:	352	Species:	Mus musculus

Alignment Length:	191	Identity:	47/191 - (24%)
Similarity:	76/191 - (39%)	Gaps:	21/191 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 EKEHGLSPDSKM-VVLHDFTPCVDDELEVKRGQLVNILYRENDWVYVIGQDSRQEGFI--PFSYC 112
            :|..|..||.:: ..|..|    |:..|:....:.|:|  |.|    |.|.|:....:  ...|.
Mouse   172 KKRQGKIPDEELRQALEKF----DESKEIAESSMFNLL--EMD----IEQVSQLSALVQAQLEYH 226

  Fly   113 APCNTQLADLAVKKKLPREQCPEQPIEENIPLLGTDNKLDVLCDETLNPGSANSIENTLLVEPEC 177
            ......|..:.|:.:....|...||..|..|  .....|:....::..|....|...|    |:
Mouse   227 KQAVQILQQVTVRLEERIRQASSQPRREYQP--KPRMSLEFATGDSTQPNGGLSHTGT----PK- 284

  Fly   178 TPFVKEPSGRCIVLYTFIARDENDLSVERGEFVTVLNREDPDWFWIMRSDGQEGFVPASFI 238
            .|.|:.....|..||.|...:|.:|..:.|:.:|:.|:.|.:|:..| ..||.||.|.:::
Mouse   285 PPGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGM-LHGQSGFFPINYV 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	11/52 (21%)
		SH3	184..238	CDD:214620	17/53 (32%)
		SH3	293..346	CDD:212690
Sh3gl2	NP_062408.2	Binds and tubulates liposomes. /evidence=ECO:0000250	1..125
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Membrane-binding amphipathic helix. /evidence=ECO:0000250	1..21
		BAR_Endophilin_A1	25..247	CDD:153297	18/84 (21%)
		Required for dimerization upon membrane association. /evidence=ECO:0000250	60..87
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..289		5/29 (17%)
		SH3_Endophilin_A	293..347	CDD:212737	17/53 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839798
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930