DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and nphp-1

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_496298.1	Gene:	nphp-1 / 174643	WormBaseID:	WBGene00010898	Length:	682	Species:	Caenorhabditis elegans

Alignment Length:	200	Identity:	45/200 - (22%)
Similarity:	83/200 - (41%)	Gaps:	38/200 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LSPDSKMVVLHDFTPCVDDELEVKR------GQLVNILYRENDWVYVIGQDSRQEGFIPFSYCAP 114
            |||:.:.:   .|:..||.:.|.::      |:..:.:|.:::     .:||..:     |....
Worm    92 LSPEKEQL---SFSVSVDSQSEEEKPKMAAIGRRKSTMYNDDE-----SEDSDND-----SEIIE 143

  Fly   115 CNTQLAD-LAVKKKLPREQ------CPEQPIEENIPL----LGTDNKLDVLCDETLNPGSANSIE 168
            .:.||.| |..:.:.|::|      .|.|||....||    |....:||.:.....||...:|.|
Worm   144 TDVQLDDPLPSQPQPPQQQHQQPQPKPRQPITITKPLESKTLNERQELDEVISRLQNPSRGDSGE 208

  Fly   169 NTLLVEPECTPFVKEPSGRCIVLYTFIARDENDLSVERGEFVTVLNREDPDWFWIMRSDGQEGFV 233
               ::||     |.......:.:.::.|..|.||.:.:|:...:.......|:..:...||.|.|
Worm   209 ---VMEP-----VVVRGNVFVAIDSWDAEAEGDLELIKGKKYRITQTRSDGWWTALDEYGQRGLV 265

  Fly   234 PASFI 238
            |.:::
Worm   266 PKTYL 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	8/55 (15%)
		SH3	184..238	CDD:214620	11/53 (21%)
		SH3	293..346	CDD:212690
nphp-1	NP_496298.1	SH3	220..271	CDD:302595	11/50 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100