DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and Sorbs2

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_038950035.1	Gene:	Sorbs2 / 114901	RGDID:	620061	Length:	1811	Species:	Rattus norvegicus

Alignment Length:	372	Identity:	79/372 - (21%)
Similarity:	138/372 - (37%)	Gaps:	99/372 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFL-CPVRMRRDK----KKAT-----NASIERDLPAVGVLGMGRITGSSSIETLV-RVGIEKEH 54
            :||| .||..||.|    :|.|     .||:...|             .|:::.:. ::..||..
  Rat  1101 LAFLVSPVPFRRKKVLTPQKQTEQAKCKASVVEAL-------------DSALKDICDQIKAEKRR 1152

  Fly    55 GLSPDSKMV--VLHDFTPCVDDELEVKRGQLVNILYRENDWVYVIGQDSRQEGFIPFSYCAPCNT 117
            |..||:.::  ::.:..|.:.:     |...:|.|.|          ....:.|.|..
  Rat  1153 GSLPDNSILHRLISELLPQIPE-----RNSSLNALKR----------SPMHQPFHPLP------- 1195

  Fly   118 QLADLAVKKKLPREQCPEQPIEENIPLLGTDNKL------DVL-CDETLNPGSANS----IENTL 171
              .|.|:...|.:..|...|...:.|.:.|.:..      .|| ..:..:|.|.:|    :..::
  Rat  1196 --QDGAIHCPLYQNDCGRMPHSASFPDVDTTSSYHAQDYGSVLSLQDHESPRSYSSTLTDLGRSV 1258

  Fly   172 LVEPECTP--FVKEPSGRCIVLYTFIARDENDLSVERGEFVTVLNREDPDWFWIMRSDGQEGFVP 234
            ..|...||  .||.|:.   .:|.|.|:...:||.::|:.|.:|.:.|.:|: .....|:.|..|
  Rat  1259 SRERRGTPEKEVKLPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWY-EGEHHGRVGIFP 1319

  Fly   235 ASFIYPADSVRVLQQQKATLNAMETILQQGQQGQQSQQQQQPQLGLGTDDLRYHGTELVMLYDYK 299
            .|::     .::...:||........:|.|:.|                       |.:..|::.
  Rat  1320 ISYV-----EKLTPPEKAQPARPPPPVQPGEIG-----------------------EAIAKYNFN 1356

  Fly   300 AQAPDDLYLSVRRGDWIYADLTNQTVDGWLWAYAPKTRKYGFIPKAY 346
            |..  ::.||:|:||.|.  |..:....|.....|.|.:.|..|.:|
  Rat  1357 ADT--NVELSLRKGDRII--LLKRVDQNWYEGKIPGTNRQGIFPVSY 1399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	7/51 (14%)
		SH3	184..238	CDD:214620	15/53 (28%)
		SH3	293..346	CDD:212690	14/52 (27%)
Sorbs2	XP_038950035.1	Sorb	377..427	CDD:128735
		SH3_Sorbs2_1	1272..1326	CDD:212853	15/62 (24%)
		SH3_Sorbs2_2	1347..1403	CDD:212856	17/80 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343641
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840