DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and sh3rf2

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_009289332.1	Gene:	sh3rf2 / 100537944	ZFINID:	ZDB-GENE-141212-301	Length:	769	Species:	Danio rerio

Alignment Length:	369	Identity:	79/369 - (21%)
Similarity:	119/369 - (32%)	Gaps:	130/369 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LHDFTPCVDDELEVKRGQLVNILYREND-WVYVIGQDSRQEGFIPFSYCAPCNTQLADLAVKKKL 128
            |:||......||.:|.|.::.:.:|.:| |.|..|:|||  |.:|.:.          |.|..:.
Zfish   125 LYDFQGNAPGELTMKSGDIIYLRWRVDDNWYYGEGKDSR--GLVPVNV----------LQVLSEQ 177

  Fly   129 PREQCPEQPIEENIPLLGTDNKLDVLCDETLNPGSANSIENTLLVEP----ECTPFVKEPSGRCI 189
            |      ||:              .|| ..|...:||::      :|    ||..|.|   |..|
Zfish   178 P------QPL--------------ALC-RALYDFNANNL------DPEGSKECLTFFK---GDSI 212

  Fly   190 VLYTFIARD--ENDLSVERGEFVTVLNREDPDWFWIMRSDGQEGFVPASFIYPADSVRV------ 246
            .|...:..:  |..|..:.|.|...|...:|..:.::....:...|.|.   |..||||
Zfish   213 TLLKQVNENWVEGKLGDKVGIFPLQLTEPNPAAYELLEKHKRRDSVEAQ---PRSSVRVNADACI 274

  Fly   247 ---------LQQQKATLNAMETI----LQQGQQ------GQQSQQQQQPQLG-LGTDDLRYHGTE 291
                     ...:.:.:|.:.::    |...||      ..|....:.|||. .....||.....
Zfish   275 HRRLTGPSQKSSRPSNVNLLNSLNCPPLSLSQQPPHISSSAQPSYSKTPQLATFNRPRLRSSRRN 339

  Fly   292 L--------------------------------------------VMLYDYKAQAPDDLYLSVRR 312
            |                                            ..||.|.....::|.|  |:
Zfish   340 LPKRHRTMNGESPPAITMALINPQASPMPSESKMSATQQLSISVCAALYSYTPYRSEELEL--RK 402

  Fly   313 GDW--IYADLTNQTVDGWLWAYAPKTRKYGFIPKAYARPPAMTS 354
            |:.  :|...:    :|||...:.||.|.|.:|..|..|...||
Zfish   403 GEMVGVYGKFS----EGWLRGLSLKTGKVGILPTNYVTPVLRTS 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	17/46 (37%)
		SH3	184..238	CDD:214620	11/55 (20%)
		SH3	293..346	CDD:212690	16/54 (30%)
sh3rf2	XP_009289332.1	RING_Ubox	8..54	CDD:327409
		SH3	122..173	CDD:327375	18/59 (31%)
		SH3	183..237	CDD:327375	17/63 (27%)
		SH3	384..437	CDD:327375	17/58 (29%)
		SH3	710..763	CDD:327375
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583881
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840