DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and arhgef38

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_009289887.1	Gene:	arhgef38 / 100317614	ZFINID:	ZDB-GENE-090313-83	Length:	762	Species:	Danio rerio

Alignment Length:	285	Identity:	56/285 - (19%)
Similarity:	112/285 - (39%)	Gaps:	80/285 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LCPVRMRRDKKKATNASIERDLPAVGVLGMGRITGSSSIETLVRVGIEKEHG------------- 55
            :|.|::.|....|....::: || |.:.....:. :|.:|.|..:|..||:.
Zfish   502 ICIVKLIRKLMDAAQPPVQQ-LP-VPLSNFNEVQ-NSIMEELSNLGFFKENSQKLMERKVSFEKR 563

  Fly    56 ---LSP-------DSKMVVLHDF------------TPCVDDELEVKRGQLVNILYRENDWVYVIG 98
               ::|       :.:..:|.::            ..|.:.::.:..|:||.:| .:.|   .:|
Zfish   564 EKKMAPEILRQTEEQRARLLEEYPVKQLYQLKRNCNACQEKDISLLEGELVALL-EDRD---PMG 624

  Fly    99 QDSR-------QEGFIPFSYCAPCNTQLADLAVKKKLPREQCPEQPIE-ENIPLLGTDNKLDVLC 155
            ..||       .:|::..|:....|            |:.:..|:|.: :|:.|..:.::
Zfish   625 SSSRWLVHTGSVQGYVYSSFLKAYN------------PQREVTERPDDFDNLSLFVSASR----- 672

  Fly   156 DETLNPGSANSIENTLLVEPECTP---FVKEPSGRCIVLYTFIARDENDLSVERGEFVTVLNRED 217
                 ..|..|...:..|.|:..|   ...........:|.|.||.|.:|:::..:.|.:|...|
Zfish   673 -----SSSMRSFSTSDSVSPQSAPQDELDTSDDQHFYAVYAFKARCEQELTLQEYQHVRILQFSD 732

  Fly   218 ----PDWFWIMRSDGQEGFVPASFI 238
                .|| |:..|:||:|:|||:::
Zfish   733 LGGNKDW-WLAESNGQKGYVPANYL 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	11/68 (16%)
		SH3	184..238	CDD:214620	19/57 (33%)
		SH3	293..346	CDD:212690
arhgef38	XP_009289887.1	RhoGEF	107..291	CDD:279015
		BAR_DNMBP	343..524	CDD:153273	6/23 (26%)
		SH3	591..646	CDD:302595	11/58 (19%)
		SH3_DNMBP_C2	703..758	CDD:213017	19/55 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	1	0.960