DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlish and sh3gl1a

DIOPT Version :9

Sequence 1:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_005168475.1	Gene:	sh3gl1a / 100005753	ZFINID:	ZDB-GENE-030131-4524	Length:	366	Species:	Danio rerio

Alignment Length:	293	Identity:	59/293 - (20%)
Similarity:	100/293 - (34%)	Gaps:	88/293 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CPVRMRRDKKKATN---ASIERDLPAVGVLGMGRITGSSSIETLVRVGIEKEHGLSPDSKMVVLH 66
            |.::..||..:.||   |.:|          ||        |.:.|:. |.:..|..|.|...:.
Zfish    96 CMLKYGRDMGEDTNFGGALVE----------MG--------EAMKRLA-EVKDSLDIDVKQNFID 141

  Fly    67 DFTPCVDDELEVKRGQLVNILYRENDWVYVIGQDSRQEGFIP----------------------- 108
            .|...||.:|:..:..|..:..|..|:.|    ..:::|.|.
Zfish   142 PFQTIVDKDLKDIQHHLKKLEGRRLDYDY----KKKRQGKIADEELRMAMEKFEESRDAAETSMQ 202

  Fly   109 ----------FSYCAPCNTQ----------LADL--AVKKKLPREQCPEQPIEENIPLLGTDNKL 151
                      ...||...:|          |.:|  |:::::.:.|  .||.::.:|:  :...:
Zfish   203 NLLDTDVEQVSQLCALVESQLQFHKQSMQVLEELAGAMRERVNKAQ--SQPRQKRMPV--SRPSI 263

  Fly   152 DVLCDETLNPGSANSIENTLLVEPECTPFVKEPSGR----------CIVLYTFIARDENDLSVER 206
            |....|..|.|...|............|.....|.|          |..||.|...:|.:|....
Zfish   264 DYSDPEDSNGGWNPSAAAPPSYSSTAAPSFNRASSRQKRNSADQPCCRALYDFEPENEGELGFNE 328

  Fly   207 GEFVTVLNREDPDWF-WIMRSDGQEGFVPASFI 238
            |:.:|:.|:.|.:|: ...|  ||.|..|.:::
Zfish   329 GDVITLTNQIDDNWYEGSFR--GQTGLFPCNYV 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlish	NP_611251.2	SH3	61..111	CDD:212690	11/82 (13%)
		SH3	184..238	CDD:214620	18/64 (28%)
		SH3	293..346	CDD:212690
sh3gl1a	XP_005168475.1	BAR_Endophilin_A	25..247	CDD:153276	31/173 (18%)
sh3gl1a	XP_005168475.1	SH3_Endophilin_A	308..362	CDD:212737	16/54 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583882
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930