DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment swi2 and Islr

DIOPT Version :9

Sequence 1:	NP_611247.3	Gene:	swi2 / 37010	FlyBaseID:	FBgn0034262	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001119772.1	Gene:	Islr / 686539	RGDID:	1596359	Length:	428	Species:	Rattus norvegicus

Alignment Length:	248	Identity:	56/248 - (22%)
Similarity:	96/248 - (38%)	Gaps:	59/248 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ETISLFC-MILIRLSRAADDSHETSTLLATITTITTEIIPMPDSGRSCFGWSSAPEAAGGNCSRS 77
            :.:.|.| ::|:.|.||..::                    .|.|.. :|:..|      :|:..
  Rat     2 QALCLLCWVVLLNLVRACPEA--------------------CDCGEK-YGFQIA------DCAYR 39

  Fly    78 NRNGTLKCYGGMNNLAALNQS---------GKLSRVQPALEMLLCGWPKDGLNHFRD-----LQK 128
            :.:|...  |...|:..|:.|         |....| |.|:.|   |...  |..|.     |..
  Rat    40 DLDGVPP--GFPANVTTLSLSANRLPVLLEGSFREV-PLLQSL---WLAH--NEIRSVAVGALAP 96

  Fly   129 LPRLRSLTIEYSGFTEFKF-DFPEMLELHTINISWTNLSYISSRTFKRVHPLKVLDLRWNQLIQL 192
            |..|:||.:.::..:||.: |...:..|..:.:....|::|....|:.:|.|:.|.|..|:|..|
  Rat    97 LGHLKSLDLSHNLISEFAWSDLHNLSALQLLKMDSNELAFIPRDAFRSLHALRSLQLNHNRLHAL 161

  Fly   193 -DGPLLLPRNFEQLYLAGNPWNCTRN---FK-WLLLQPEKGRLVVDRDELICT 240
             :|......:...|.:..||::||..   || |.|.....   :.::|.:.||
  Rat   162 AEGTFAPLTSLSHLQINHNPFDCTCGIVWFKTWALATAVS---IPEQDNIACT 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
swi2	NP_611247.3	LRR	<117..384	CDD:227223	34/135 (25%)
		leucine-rich repeat	132..154	CDD:275378	6/22 (27%)
		leucine-rich repeat	155..178	CDD:275378	4/22 (18%)
		leucine-rich repeat	179..201	CDD:275378	7/22 (32%)
		leucine-rich repeat	202..214	CDD:275378	3/11 (27%)
		leucine-rich repeat	287..307	CDD:275378
		leucine-rich repeat	308..332	CDD:275378
		leucine-rich repeat	333..357	CDD:275378
		leucine-rich repeat	358..385	CDD:275378
		leucine-rich repeat	386..398	CDD:275378
Islr	NP_001119772.1	leucine-rich repeat	32..51	CDD:275380	4/26 (15%)
		LRR_8	51..110	CDD:404697	16/64 (25%)
		leucine-rich repeat	52..75	CDD:275380	4/23 (17%)
		leucine-rich repeat	76..99	CDD:275380	7/27 (26%)
		LRR_8	99..158	CDD:404697	15/58 (26%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		leucine-rich repeat	124..147	CDD:275380	4/22 (18%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		PCC	153..>227	CDD:188093	17/62 (27%)
		Ig	239..343	CDD:416386
		Ig strand C	265..287	CDD:409353
		Ig strand C'	288..290	CDD:409353
		Ig strand D	304..307	CDD:409353
		Ig strand E	310..316	CDD:409353
		Ig strand F	323..331	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24366
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100