Protein Alignment swi2 and ISLR2

DIOPT Version :9

• Sequence 1: NP_611247.3
• Gene: swi2 / 37010
• FlyBaseID: FBgn0034262
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_001123608.1
• Gene: ISLR2 / 57611
• HGNCID: 29286
• Length: 745
• Species: Homo sapiens
• Alignment Length: 220
• Identity: 46/220 - (20%)
• Similarity: 72/220 - (32%)
• Gaps: 88/220 - (40%)

  Fly   272 CTCL---MHHILPKTHIPLYTVNCSHLQFHRLPDFLPDNTTTLVINDNMI--------SDINPLR 325
            |.|:   .|..          .:|::.:...:|:.||.|.|||.::.|.|        :|:.
Human    24 CACVDKYAHQF----------ADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVT--- 75

  Fly   326 DNPHYRHVVDMQLENNQISNVD-----------NLEDTY-------W-----LQNFRLLNLRGNN 367
                  .|..:.|.:|::..|:           ||:.::       |     |...:||.:..|.
Human    76 ------QVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNR 134

  Fly   368 LRKLHVYALDNALDD------NEN---------------ANLLLLSRNPWHCTCKFGSRMRELLT 411
            |..|...|| .||.|      |.|               .:.|.|..||:||.|..
Human   135 LGSLPRDAL-GALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGL--------- 189

  Fly   412 KYKDIVRDAWNVSCTYRLDDDQLLA 436
                :...||..|....|.:...:|
Human   190 ----VWLQAWAASTRVSLPEPDSIA 210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
swi2	NP_611247.3	LRR	<117..384	CDD:227223	32/151 (21%)
		leucine-rich repeat	132..154	CDD:275378
		leucine-rich repeat	155..178	CDD:275378
		leucine-rich repeat	179..201	CDD:275378
		leucine-rich repeat	202..214	CDD:275378
		leucine-rich repeat	287..307	CDD:275378	4/19 (21%)
		leucine-rich repeat	308..332	CDD:275378	6/31 (19%)
		leucine-rich repeat	333..357	CDD:275378	8/46 (17%)
		leucine-rich repeat	358..385	CDD:275378	11/32 (34%)
		leucine-rich repeat	386..398	CDD:275378	4/11 (36%)
ISLR2	NP_001123608.1	leucine-rich repeat	36..52	CDD:275380	4/15 (27%)
		LRR_8	52..109	CDD:404697	13/65 (20%)
		LRR 1	52..73		6/20 (30%)
		leucine-rich repeat	53..76	CDD:275380	6/31 (19%)
		LRR 2	76..97		4/20 (20%)
		leucine-rich repeat	77..100	CDD:275380	4/22 (18%)
		LRR_8	99..159	CDD:404697	16/60 (27%)
		LRR 3	100..123		3/22 (14%)
		leucine-rich repeat	101..124	CDD:275380	4/22 (18%)
		LRR 4	124..145		7/21 (33%)
		leucine-rich repeat	125..148	CDD:275380	9/23 (39%)
		LRR 5	148..169		3/20 (15%)
		leucine-rich repeat	149..172	CDD:275380	2/22 (9%)
		PCC	154..>228	CDD:188093	14/70 (20%)
		Ig_3	232..359	CDD:404760
		Ig strand B	256..263	CDD:409353
		Ig strand C	269..274	CDD:409353
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..326
		Ig strand C'	305..307	CDD:409353
		Ig strand D	331..335	CDD:409353
		Ig strand E	338..343	CDD:409353
		Ig strand F	351..359	CDD:409353
		Ig strand G	362..372	CDD:409353
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..722

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100