DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment swi2 and Islr

DIOPT Version :9

Sequence 1:	NP_611247.3	Gene:	swi2 / 37010	FlyBaseID:	FBgn0034262	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	XP_006511267.1	Gene:	Islr / 26968	MGIID:	1349645	Length:	436	Species:	Mus musculus

Alignment Length:	253	Identity:	57/253 - (22%)
Similarity:	90/253 - (35%)	Gaps:	63/253 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KAAETISLFC-MILIRLSRAADDSHETSTLLATITTITTEIIPMP-DSGRSCFGWSSAPEAAGGN 73
            :....:.|.| .:|:.|.||.                     |.| |.|.. :|:..|      :
Mouse     7 RTMRALCLLCWAVLLNLVRAC---------------------PEPCDCGEK-YGFQIA------D 43

  Fly    74 CSRSNRNG----------TLKCYGGMNNLAALNQSGKLSRVQPALEMLLCGWPKDGLNHFRD--- 125
            |:..:..|          ||..  ..|.|..|.:..  .|..|.|:.|   |...  |..|.
Mouse    44 CAYRDLEGVPPGFPANVTTLSL--SANRLPGLPEGA--FREVPLLQSL---WLAH--NEIRSVAI 99

  Fly   126 --LQKLPRLRSLTIEYSGFTEFKF-DFPEMLELHTINISWTNLSYISSRTFKRVHPLKVLDLRWN 187
              |..|..|:||.:.::..:||.: |...:..|..:.:....|::|....|..:..|:.|.|..|
Mouse   100 GALAPLSHLKSLDLSHNLLSEFAWSDLHNLSALQLLKMDSNELAFIPRDAFSSLSALRSLQLNHN 164

  Fly   188 QLIQL-DGPLLLPRNFEQLYLAGNPWNCTRN---FK-WLLLQPEKGRLVVDRDELICT 240
            :|..| :|..........|.:..||::||..   || |.|.....   :.::|.:.||
Mouse   165 RLHALAEGTFAPLTALSHLQINDNPFDCTCGIVWFKTWALASAVS---IPEQDNIACT 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
swi2	NP_611247.3	LRR	<117..384	CDD:227223	33/135 (24%)
		leucine-rich repeat	132..154	CDD:275378	6/22 (27%)
		leucine-rich repeat	155..178	CDD:275378	4/22 (18%)
		leucine-rich repeat	179..201	CDD:275378	7/22 (32%)
		leucine-rich repeat	202..214	CDD:275378	3/11 (27%)
		leucine-rich repeat	287..307	CDD:275378
		leucine-rich repeat	308..332	CDD:275378
		leucine-rich repeat	333..357	CDD:275378
		leucine-rich repeat	358..385	CDD:275378
		leucine-rich repeat	386..398	CDD:275378
Islr	XP_006511267.1	leucine-rich repeat	40..59	CDD:275380	3/24 (13%)
		LRR_8	59..118	CDD:338972	17/67 (25%)
		leucine-rich repeat	60..83	CDD:275380	6/26 (23%)
		leucine-rich repeat	84..107	CDD:275380	7/27 (26%)
		LRR_8	107..166	CDD:338972	14/58 (24%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		leucine-rich repeat	132..155	CDD:275380	4/22 (18%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		PCC	161..>235	CDD:188093	17/62 (27%)
		Ig	263..349	CDD:319273
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100