DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment swi2 and Islr2

DIOPT Version :9

Sequence 1:	NP_611247.3	Gene:	swi2 / 37010	FlyBaseID:	FBgn0034262	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	XP_003750572.2	Gene:	Islr2 / 100910729	RGDID:	6497037	Length:	746	Species:	Rattus norvegicus

Alignment Length:	214	Identity:	46/214 - (21%)
Similarity:	74/214 - (34%)	Gaps:	76/214 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 CTCL---MHHILPKTHIPLYTVNCSHLQFHRLPDFLPDNTTTLVINDNMISDINPLRDNP--HYR 331
            |.|:   .|..          .:|::.:...:|:.||.|.|||.::.|.|:   .||...  :..
  Rat    25 CACVDKYAHQF----------ADCAYKELREVPEGLPANVTTLSLSANKIT---VLRRGAFVNVT 76

  Fly   332 HVVDMQLENNQISNVD-----------NLEDTY-------W-----LQNFRLLNLRGNNLRKLHV 373
            .|..:.|.::::..|:           ||:.::       |     |...:||.:..|.|..|..
  Rat    77 QVTSLWLAHSEVRTVESGALAVLSQLKNLDLSHNLISNFPWSDLRNLSALQLLKMNHNRLGSLPR 141

  Fly   374 YALDNALDD------NEN---------------ANLLLLSRNPWHCTCKFGSRMRELLTKYKDIV 417
            .|| .||.|      |.|               .:.|.|..||:||:|..             :.
  Rat   142 DAL-GALPDLRSLRINNNRLRTLEPGTFDALSALSHLQLYHNPFHCSCGL-------------VW 192

  Fly   418 RDAWNVSCTYRLDDDQLLA 436
            ..||..|....|.:...:|
  Rat   193 LQAWAASTRVSLPEPDSIA 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
swi2	NP_611247.3	LRR	<117..384	CDD:227223	32/145 (22%)
		leucine-rich repeat	132..154	CDD:275378
		leucine-rich repeat	155..178	CDD:275378
		leucine-rich repeat	179..201	CDD:275378
		leucine-rich repeat	202..214	CDD:275378
		leucine-rich repeat	287..307	CDD:275378	4/19 (21%)
		leucine-rich repeat	308..332	CDD:275378	7/25 (28%)
		leucine-rich repeat	333..357	CDD:275378	7/46 (15%)
		leucine-rich repeat	358..385	CDD:275378	11/32 (34%)
		leucine-rich repeat	386..398	CDD:275378	4/11 (36%)
Islr2	XP_003750572.2	leucine-rich repeat	37..53	CDD:275380	4/15 (27%)
		leucine-rich repeat	54..77	CDD:275380	7/25 (28%)
		leucine-rich repeat	78..101	CDD:275380	3/22 (14%)
		LRR_8	100..160	CDD:404697	16/60 (27%)
		leucine-rich repeat	102..125	CDD:275380	4/22 (18%)
		leucine-rich repeat	126..149	CDD:275380	9/23 (39%)
		leucine-rich repeat	150..173	CDD:275380	2/22 (9%)
		PCC	155..>229	CDD:188093	14/70 (20%)
		Ig	249..374	CDD:416386
		Ig strand B	257..264	CDD:409353
		Ig strand C	270..278	CDD:409353
		Ig strand C'	280..287	CDD:409353
		Ig strand D	333..337	CDD:409353
		Ig strand E	340..345	CDD:409353
		Ig strand F	353..361	CDD:409353
		Ig strand G	364..374	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24366
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100