DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HPS4 and HPS4

DIOPT Version :9

Sequence 1:	NP_611246.1	Gene:	HPS4 / 37009	FlyBaseID:	FBgn0034261	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	XP_011528787.1	Gene:	HPS4 / 89781	HGNCID:	15844	Length:	752	Species:	Homo sapiens

Alignment Length:	897	Identity:	178/897 - (19%)
Similarity:	316/897 - (35%)	Gaps:	224/897 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 TSILTERETM----IVFVYDTECLTDEADDPISAVLYFHPSWVSDSQKVALCGQLMGTSYFLKDC 82
            ||..||.::.    ..|:||...:.:|.|...:.:.||:||.....|:..||||:.|....:.|.
Human     3 TSTSTEAKSASWWNYFFLYDGSKVKEEGDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVSDI 67

  Fly    83 FFN-PRILALQNGKFVLKEFGRFILAIGTDRNIGDQLLEHRADLLSSLLKFFHRDVQTLYAQYAA 146
            ..: |.::.|:..||.:|..|.::..:|....:.|...:...|.|.....|           |..
Human    68 SDSPPTLVRLRKLKFAIKVDGDYLWVLGCAVELPDVSCKRFLDQLVGFFNF-----------YNG 121

  Fly   147 PPALNRRNLS-EKLYHIFETYLPMLQRNGNTFQNV--PRLRMPKTASH----------------- 191
            |.:|...|.| |:|...::|::..:.:|.:....:  ....:.:|.||
Human   122 PVSLAYENCSQEELSTEWDTFIEQILKNTSDLHKIFNSLWNLDQTKSHGTWSDIKPPVSPWGLCF 186

  Fly   192 -----------IFLEAIQTLQSCQQTKGILGGAILYHNKVVASQLSDMVTKHLVLTDPLHIRTAA 245
                       :.|:|.:.||:||::..||.|.|||...:|::||...:|..::    || |||.
Human   187 RRKVEDRVEPLLLLKAARILQTCQRSPHILAGCILYKGLIVSTQLPPSLTAKVL----LH-RTAP 246

  Fly   246 EQVTNHPEFHIPNGVQMLVVYLEHMQYRQLAGEAQRAQNLQMNTAQLTQNGMPFQYAKRKIKRDK 310
            :      |..:|.|..   ...||.:: .|.....|..:...|.|.|..|              .
Human   247 Q------EQRLPTGED---APQEHGKW-MLWSFKNRVTHQNPNGAALPPN--------------V 287

  Fly   311 SLIFTHIPEEEHAPEQQGAVEQLPPARPKSMRPTHLPLRIKSMQSKELPESGIASINFDETDSYP 375
            .:|...:.:||.....:..|||:       .|....|..::...::..|:.|..|...:....:.
Human   288 QIIPVFVTKEEAISLHEFPVEQM-------TRSLASPAGLQDGSAQHHPKGGSTSALKENATGHV 345

  Fly   376 QFIGRTSVCNTPMTENKVLPVANVMSICANPED--EGKEEDIHNS-NGKTHSRRNSLKVDVEKFF 437
            :.:..|:  ..|.:.::..|.....:.|.:..|  ..:...:||| .|:.....:||
Human   346 ESMAWTT--PDPTSPDEACPDGRKENGCLSGHDLESIRPAGLHNSARGEVLGLSSSL-------- 400

  Fly   438 QNFISNPNKQLTRRKSSADLQDALRAISKKLN------NFTHGLKTDVNRNGSGNGDVSSDSPDF 496
                   .|:|...:...||.:.....::::.      .|.|....|      |.......|
Human   401 -------GKELVFLQEELDLSEIHIPEAQEVEMASGHFAFLHVPVPD------GRAPYCKAS--- 449

  Fly   497 IEDDDKITSRTISDPTYPVFNTNGQQISRSLFQQFLDQYRKLWGVASEQAHEDAELAALVAEFQE 561
                  :::.:..:||.|                                 ||..:::|
Human   450 ------LSASSSLEPTPP---------------------------------EDTAISSL------ 469

  Fly   562 FNAEIQKLDEHMRQQAAEASSADRNLNVSAAKTP-------LDKRSMTLPLKSAGESTFGER-AS 618
               ......|.:.|..|:....|...:.|.|..|       ..:|.:.||....|:.  |.: .:
Human   470 ---RPPSAPEMLTQHGAQEQLEDHPGHSSQAPIPRADPLPRRTRRPLLLPRLDPGQR--GNKLPT 529

  Fly   619 GRSGAGGVPLTPLMAKLSVLALSETTP-IEIQTPLTTSKVFPRRSSLKCEDA---VDALAALTTA 679
            |..|        |...:..:..|...| :|..:           .|..|:.|   .|.:::..|
Human   530 GEQG--------LDEDVDGVCESHAAPGLECSS-----------GSANCQGAGPSADGISSRLT- 574

  Fly   680 PAQPPGPIQPDGLQRTELYICGQQNMTLLLLMEEGTCQQQQVVQKMFDICVAKFPHMESQLNQTL 744
            ||:     ...||.|..||....:.:.|.||.||........:::::...:|....:|..|.:||
Human   575 PAE-----SCMGLVRMNLYTHCVKGLVLSLLAEEPLLGDSAAIEEVYHSSLASLNGLEVHLKETL 634

  Fly   745 NVNVEGDNRD-----GSNYSFMCVDSKWDVLQRNGPW--NPLELNILESMHSIHSSGHHLT---D 799
                   .||     .|.|:|...|....:|..|.|.  .|.:...|:::..:||....|.   :
Human   635 -------PRDEAASTSSTYNFTHYDRIQSLLMANLPQVATPQDRRFLQAVSLMHSEFAQLPALYE 692

  Fly   800 LILRSNDSVYYGHKNGRTEFFYKE--PTHQINGIPPPSDPIGNIQSRAKSRL 849
            :.:|:..:..|...|...|.::::  |..:.:|.|.|.|...::..:||.:|
Human   693 MTVRNASTAVYACCNPIQETYFQQLAPAARSSGFPNPQDGAFSLSGKAKQKL 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HPS4	NP_611246.1	None
HPS4	XP_011528787.1	dnaA	<458..>575	CDD:237605	15/116 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159614
Domainoid	1	1.000	122	1.000	Domainoid score	I5636
eggNOG	1	0.900	-	-		E1_28K4F
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4744
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008034
OrthoInspector	1	1.000	-	-		oto91206
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14407
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.940