Protein Alignment HPS4 and HPS4

DIOPT Version :10

• Sequence 1: NP_611246.1
• Gene: HPS4 / 37009
• FlyBaseID: FBgn0034261
• Length: 858
• Species: Drosophila melanogaster
• Sequence 2: XP_011528788.1
• Gene: HPS4 / 89781
• HGNCID: 15844
• Length: 752
• Species: Homo sapiens
• Alignment Length: 897
• Identity: 178/897 - (19%)
• Similarity: 316/897 - (35%)
• Gaps: 224/897 - (24%)

  Fly    22 TSILTERETM----IVFVYDTECLTDEADDPISAVLYFHPSWVSDSQKVALCGQLMGTSYFLKDC 82
            ||..||.::.    ..|:||...:.:|.|...:.:.||:||.....|:..||||:.|....:.|.
Human     3 TSTSTEAKSASWWNYFFLYDGSKVKEEGDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVSDI 67

  Fly    83 FFN-PRILALQNGKFVLKEFGRFILAIGTDRNIGDQLLEHRADLLSSLLKFFHRDVQTLYAQYAA 146
            ..: |.::.|:..||.:|..|.::..:|....:.|...:...|.|.....|           |..
Human    68 SDSPPTLVRLRKLKFAIKVDGDYLWVLGCAVELPDVSCKRFLDQLVGFFNF-----------YNG 121

  Fly   147 PPALNRRNLS-EKLYHIFETYLPMLQRNGNTFQNV--PRLRMPKTASH----------------- 191
            |.:|...|.| |:|...::|::..:.:|.:....:  ....:.:|.||
Human   122 PVSLAYENCSQEELSTEWDTFIEQILKNTSDLHKIFNSLWNLDQTKSHGTWSDIKPPVSPWGLCF 186

  Fly   192 -----------IFLEAIQTLQSCQQTKGILGGAILYHNKVVASQLSDMVTKHLVLTDPLHIRTAA 245
                       :.|:|.:.||:||::..||.|.|||...:|::||...:|..::    || |||.
Human   187 RRKVEDRVEPLLLLKAARILQTCQRSPHILAGCILYKGLIVSTQLPPSLTAKVL----LH-RTAP 246

  Fly   246 EQVTNHPEFHIPNGVQMLVVYLEHMQYRQLAGEAQRAQNLQMNTAQLTQNGMPFQYAKRKIKRDK 310
            :      |..:|.|..   ...||.:: .|.....|..:...|.|.|..|              .
Human   247 Q------EQRLPTGED---APQEHGKW-MLWSFKNRVTHQNPNGAALPPN--------------V 287

  Fly   311 SLIFTHIPEEEHAPEQQGAVEQLPPARPKSMRPTHLPLRIKSMQSKELPESGIASINFDETDSYP 375
            .:|...:.:||.....:..|||:       .|....|..::...::..|:.|..|...:....:.
Human   288 QIIPVFVTKEEAISLHEFPVEQM-------TRSLASPAGLQDGSAQHHPKGGSTSALKENATGHV 345

  Fly   376 QFIGRTSVCNTPMTENKVLPVANVMSICANPED--EGKEEDIHNS-NGKTHSRRNSLKVDVEKFF 437
            :.:..|:  ..|.:.::..|.....:.|.:..|  ..:...:||| .|:.....:||
Human   346 ESMAWTT--PDPTSPDEACPDGRKENGCLSGHDLESIRPAGLHNSARGEVLGLSSSL-------- 400

  Fly   438 QNFISNPNKQLTRRKSSADLQDALRAISKKLN------NFTHGLKTDVNRNGSGNGDVSSDSPDF 496
                   .|:|...:...||.:.....::::.      .|.|....|      |.......|
Human   401 -------GKELVFLQEELDLSEIHIPEAQEVEMASGHFAFLHVPVPD------GRAPYCKAS--- 449

  Fly   497 IEDDDKITSRTISDPTYPVFNTNGQQISRSLFQQFLDQYRKLWGVASEQAHEDAELAALVAEFQE 561
                  :::.:..:||.|                                 ||..:::|
Human   450 ------LSASSSLEPTPP---------------------------------EDTAISSL------ 469

  Fly   562 FNAEIQKLDEHMRQQAAEASSADRNLNVSAAKTP-------LDKRSMTLPLKSAGESTFGER-AS 618
               ......|.:.|..|:....|...:.|.|..|       ..:|.:.||....|:.  |.: .:
Human   470 ---RPPSAPEMLTQHGAQEQLEDHPGHSSQAPIPRADPLPRRTRRPLLLPRLDPGQR--GNKLPT 529

  Fly   619 GRSGAGGVPLTPLMAKLSVLALSETTP-IEIQTPLTTSKVFPRRSSLKCEDA---VDALAALTTA 679
            |..|        |...:..:..|...| :|..:           .|..|:.|   .|.:::..|
Human   530 GEQG--------LDEDVDGVCESHAAPGLECSS-----------GSANCQGAGPSADGISSRLT- 574

  Fly   680 PAQPPGPIQPDGLQRTELYICGQQNMTLLLLMEEGTCQQQQVVQKMFDICVAKFPHMESQLNQTL 744
            ||:     ...||.|..||....:.:.|.||.||........:::::...:|....:|..|.:||
Human   575 PAE-----SCMGLVRMNLYTHCVKGLVLSLLAEEPLLGDSAAIEEVYHSSLASLNGLEVHLKETL 634

  Fly   745 NVNVEGDNRD-----GSNYSFMCVDSKWDVLQRNGPW--NPLELNILESMHSIHSSGHHLT---D 799
                   .||     .|.|:|...|....:|..|.|.  .|.:...|:::..:||....|.   :
Human   635 -------PRDEAASTSSTYNFTHYDRIQSLLMANLPQVATPQDRRFLQAVSLMHSEFAQLPALYE 692

  Fly   800 LILRSNDSVYYGHKNGRTEFFYKE--PTHQINGIPPPSDPIGNIQSRAKSRL 849
            :.:|:..:..|...|...|.::::  |..:.:|.|.|.|...::..:||.:|
Human   693 MTVRNASTAVYACCNPIQETYFQQLAPAARSSGFPNPQDGAFSLSGKAKQKL 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPS4	NP_611246.1	Intu_longin_1	31..135	CDD:436911	27/108 (25%)
		Intu_longin_3	754..848	CDD:436913	24/105 (23%)
HPS4	XP_011528788.1	Intu_longin_1	15..121	CDD:436911	27/106 (25%)
		dnaA	<458..>575	CDD:455861	15/116 (13%)
		Intu_longin_3	642..743	CDD:436913	27/108 (25%)