DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HPS4 and hps4

DIOPT Version :9

Sequence 1:	NP_611246.1	Gene:	HPS4 / 37009	FlyBaseID:	FBgn0034261	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	XP_012820762.2	Gene:	hps4 / 779927	XenbaseID:	XB-GENE-941395	Length:	689	Species:	Xenopus tropicalis

Alignment Length:	845	Identity:	174/845 - (20%)
Similarity:	307/845 - (36%)	Gaps:	211/845 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FVYDTECLTDEADDPISAVLYFHPSWVSDSQKVALCGQLMGTSYFLKD-CFFNPRILALQNGKFV 97
            |:||...:..|.|...:.:.||:|......|:..||||:.|....:.: ...:|.::.|:..||.
Frog    19 FLYDGSKVRGEGDPTRAGINYFYPPQTILDQQELLCGQIAGVVRCMTEVANSSPNLIRLRKLKFA 83

  Fly    98 LKEFGRFILAIGTDRNIGDQLLEHRADLLSSLLKFFHRDVQTLYAQYAAPPALNRRNLSEKLYHI 162
            :...|.::.|:|...::.|...:|....|..|..|::..:|..|...:.....:..||
Frog    84 IVVDGDYLWALGCSVDVTDVSCKHFLQELIGLFLFYNGPLQYAYEVRSQAELDSEWNL------- 141

  Fly   163 FETYLPMLQRNGNT-----FQNVPRLRMPKTASHIFLEAIQTLQSCQQTKGILGGAILYHNKVVA 222
               |:..:| |..|     |.::..|...|....:.|:|...||:||:...||.|.|||.|.:|:
Frog   142 ---YIEFIQ-NTTTDLHRIFNSLSHLDKTKVDPLLLLKAALILQTCQRFPNILAGCILYKNHIVS 202

  Fly   223 SQLSDMVTKHLVLTDPLHIRTAAEQVTNHPEFHIPNGVQMLVVYLEHMQYRQLAGEAQRAQNLQM 287
            :||...:|..:::.....:::.:.:  |..:..:|..|.|:.|::...:...|     |....|.
Frog   203 TQLPPSLTSKILIQRVGLVQSPSSE--NSSDVALPQDVYMIPVFVMENEITSL-----RHYPAQW 260

  Fly   288 NTAQLTQNGMPFQYAKRKIKRDKSLIFTHIPEEEHAPEQQGAVEQLPPARPKSMRPTHLPLRIKS 352
            .|...|.:.....::....|:.....|. :.|:.......|:.|         :.|.|||
Frog   261 MTRMPTPSKTLSSFSPSLSKKASGNQFL-VSEDSTQEGTTGSGE---------LSPVHLP----- 310

  Fly   353 MQSKELPESGI-ASINFDETDSYPQFIGRTSVCNTPMTENKVLPVANVMS----ICANPEDEGKE 412
              ::|.|..|| |.|..|:...                    ||.|::|.    .|::|
Frog   311 --TEEAPLQGIGAGILADKVAE--------------------LPFADLMKDSPMQCSSP------ 347

  Fly   413 EDIHNSNGKTHSRR----NSLKV--DVEKFFQNFISNPNKQLTRRKSSADLQDALRAISKKLNNF 471
            .::.|..|:|...:    ::||.  |......|.:....||.|   .|.:::|         ||:
Frog   348 VNLLNKQGRTGKCKPPGGSTLKTLSDTSSSLYNLVLIVPKQKT---ISQEIED---------NNY 400

  Fly   472 THGLKTDVNRNGSGNGDVSSDSPDFIEDDDKITSRTISDPTYPVFNTNGQQISRSLFQQFLDQYR 536
            ...|.|       |:........||...:|.:.:                      |:.::...:
Frog   401 RERLST-------GSFATCDSMMDFENKEDGLET----------------------FEDYVPVSQ 436

  Fly   537 KLWGVASEQAHEDAELAALVAEFQEFNAE----IQKLDEHMRQQ-AAEASSADRNLNVSAAKTPL 596
            |  ..:|...:||          |.::.|    ::|.:....|| ..|.|:.|..|..|:
Frog   437 K--DNSSTVTNED----------QTYSCEQSILLEKPENRNNQQDNPEYSTNDGTLEKSS----- 484

  Fly   597 DKRSMTLPLKSAGESTFGERASGRSGAGGVPLTPLMAKLSVLALSETTPIEIQTPLTTSKVFPRR 661
                   |.....:..|..:.|.            ::..|:|.  ::||....|.|.
Frog   485 -------PSSQTTDINFSPKGSN------------VSDWSLLV--DSTPSSNSTQLV-------- 520

  Fly   662 SSLKCEDAVDALAALTTAPAQPPGPIQPDGLQRTELYICGQQNMTLLLLMEEGTCQQQQVVQKMF 726
                                            :..||:...:.:.|.||.|......:..||.::
Frog   521 --------------------------------QLMLYVHNVKGLVLALLAECPLQHDKASVQDVY 553

  Fly   727 DICVAKFPHMESQLNQTLNVNVEGDNRDGSNYSFMCVDSKWDVLQRNGP--WNPLELNILESMHS 789
            |..:|....:|..|.:||.||  ..|...|:|||...|....:|..|.|  .:..:.:.|.:...
Frog   554 DSTLASLNGLEVHLKETLTVN--NSNLTKSSYSFTHYDPIQHILTANLPSVSSTHDRHFLRAASL 616

  Fly   790 IHSS-GHH--LTDLILRSNDSVYYGHKNGRTEFFYKE--PTHQINGIPPPSDPIGNIQSRAKSRL 849
            |||. ..|  ..::.:|:..|..||.::...|.::::  |..:.:|:|.|.|....:.|:||.:|
Frog   617 IHSDFNQHQSFQEITVRNASSAIYGCQSAVHETYFQQLAPPIRNSGVPDPQDSAFVLSSKAKQKL 681

Fly 850 849
Frog 682 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HPS4	NP_611246.1	None
hps4	XP_012820762.2	Intu_longin_1	15..121	CDD:408801	26/101 (26%)
hps4	XP_012820762.2	Intu_longin_3	579..680	CDD:408803	26/100 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5331
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	126	1.000	Inparanoid score	I4542
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008034
OrthoInspector	1	1.000	-	-		oto104986
Panther	1	1.100	-	-	LDO	PTHR14407
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.150