DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HPS4 and Hps4

DIOPT Version :9

Sequence 1:	NP_611246.1	Gene:	HPS4 / 37009	FlyBaseID:	FBgn0034261	Length:	858	Species:	Drosophila melanogaster
Sequence 2:	NP_001100618.2	Gene:	Hps4 / 304555	RGDID:	1308070	Length:	661	Species:	Rattus norvegicus

Alignment Length:	862	Identity:	175/862 - (20%)
Similarity:	278/862 - (32%)	Gaps:	273/862 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FVYDTECLTDEADDPISAVLYFHPSWVSDSQKVALCGQLMGTSYFLKDCFFN-PRILALQNGKFV 97
            |:||...:..|.|...:.:.||:||.....|:..|||||.|....|.|.... |.::.|:|.||.
  Rat    19 FLYDGSKVQGEGDPTRAGICYFYPSQTLLDQQELLCGQLAGVVRCLWDLSGTPPMLIRLRNLKFA 83

  Fly    98 LKEFGRFILAIGTDRNIGDQLLEHRADLLSSLLKFFHRDVQTLYAQYAAPPALNRRNLSEKLYHI 162
            |:..|.::.|:|....:.|....   ..|..|:.|||..:..:...|.:.|       .|:|...
  Rat    84 LRVDGDYLWALGCGVELSDASCR---QFLDQLIGFFHFYMGPVSLAYKSHP-------QEELRLQ 138

  Fly   163 FETYLPMLQRNG-------NTFQNVPRLRMPKTASHIFLEAIQTLQSCQQTKGILGGAILYHNKV 220
            ::|::..:.|:.       |...|:.|   .|....:.|:|...||:||::..:|.|.|||...:
  Rat   139 WDTFITQVLRSTSESHRIFNALWNLDR---TKVEPLLLLKAALILQTCQRSPHVLAGCILYEGLI 200

  Fly   221 VASQLSDMVTKHLVLTDPLHIRTAAEQ-------VTNHPEFHIPNGVQMLVVYLEHMQYRQLAGE 278
            |.|||...:|..::    ||...||:|       .|......:|..||:..|:|...:...|
  Rat   201 VNSQLPPSLTAKVL----LHHTVAADQRPPGAGAATQETGPALPPAVQITPVFLSEEEVASL--- 258

  Fly   279 AQRAQNLQMNTAQLTQNGMPFQYAKRKIKRDKSLIFTHIPEEEHAPEQQGAVEQLPP---ARPKS 340
                                                 |....||.|..:.:..|.||   :.|..
  Rat   259 -------------------------------------HEFPVEHDPRLEESSFQCPPWDQSTPTG 286

  Fly   341 ----------MRPT-----HLPLRIKSMQSKELPESGIASINFDETDSYPQFIGRTSVCNTPMTE 390
                      :.||     |.| |::..::                       |.|.:|......
  Rat   287 AEDAWTSATVLEPTPCGGGHSP-RLEQERA-----------------------GPTGLCTEACDR 327

  Fly   391 NKVLPVANVMSICANPEDEGKEEDIHNSNGKTHSRRNSLKVDVEKFFQNFISNPNKQLTRRKSSA 455
            :..|.......:|.:.|                       :|:...   .:|..........:|.
  Rat   328 SSDLSGRLQRELCLSQE-----------------------LDLSAM---HLSEAQDAFPPVPASC 366

  Fly   456 DLQDALRAISKKLNNFTHGLKTDVNRNGSGNGDVSSDSPDFIEDDDKITSRTISDPTYPVFNTNG 520
            |||...                           ||.|:|. :.:|..|.|  ..||: |:
  Rat   367 DLQALC---------------------------VSRDTPT-LPEDTAICS--CLDPS-PL----- 395

  Fly   521 QQISRSLFQQFLDQYRKLWGVASEQAHEDAELAALVAEFQEFNAEIQKLDEHMRQQAAEASSADR 585
                                   |:..|...|.||        |::.....|......|...:.|
  Rat   396 -----------------------ERPPEGGSLEAL--------ADLPLTHGHTHVPGTEPLPSSR 429

  Fly   586 NLNVSAAKTPLDKRSMTLPLKSAGESTFGERASGRSGAGGVPLTPLMAKLSVLALSE-TTPIEIQ 649
            .:             :.||....|.    |......|:|.....|.:|:.|..|.|: .:|...:
  Rat   430 TM-------------VLLPQHPEGV----EPGVEPCGSGAQDRLPALARSSHSADSQGPSPSADR 477

  Fly   650 TPLTTSKVFPRRSSLKCEDAVDALAALTTAPAQPPGPIQPDGLQRTELYICGQQNMTLLLLMEEG 714
            |....|                           |.||  ..||....||......:.|.||.:|.
  Rat   478 TGFNPS---------------------------PSGP--HAGLMPMNLYTHSVNGLVLSLLAKET 513

  Fly   715 TCQQQQVVQKMFDICVAKFPHMESQLNQTLNVNVEGDNRD-----GSNYSFMCVDSKWDVLQRN- 773
            .......:::::...:|....:|..|.:||       .||     ||.|:|:..|....||..|
  Rat   514 LGSDTAAIEEVYHSSLASLNGLEVHLKETL-------PRDETSPTGSTYNFLHYDRIQSVLSANL 571

  Fly   774 ----GPWNPLELNILESMHSIHSSGHHLTDLILRSNDSVYYGHKNGRTEFFYKE--PTHQINGIP 832
                .|.|...|..:..|||..:....|.::.:|:..:..|...|...|.::::  ||.:.:|.|
  Rat   572 PLVAAPQNRRFLQAVNLMHSDFAQLPMLYEMTIRNASTAVYACSNPAQETYFQQLAPTARSSGFP 636

  Fly   833 PPSDPIGNIQSRAKSRL 849
            .|.|...::..:||.:|
  Rat   637 NPQDCAFSLSGKAKQKL 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HPS4	NP_611246.1	None
Hps4	NP_001100618.2	Intu_longin_1	15..121	CDD:408801	33/104 (32%)
		PHA03307	225..>490	CDD:223039	68/467 (15%)
		Intu_longin_3	551..652	CDD:408803	27/100 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353664
Domainoid	1	1.000	120	1.000	Domainoid score	I5600
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	121	1.000	Inparanoid score	I4672
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008034
OrthoInspector	1	1.000	-	-		oto98292
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14407
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.990