Protein Alignment HPS4 and Hps4

DIOPT Version :10

• Sequence 1: NP_611246.1
• Gene: HPS4 / 37009
• FlyBaseID: FBgn0034261
• Length: 858
• Species: Drosophila melanogaster
• Sequence 2: NP_619587.3
• Gene: Hps4 / 192232
• MGIID: 2177742
• Length: 671
• Species: Mus musculus
• Alignment Length: 867
• Identity: 180/867 - (20%)
• Similarity: 286/867 - (32%)
• Gaps: 273/867 - (31%)

  Fly    34 FVYDTECLTDEADDPISAVLYFHPSWVSDSQKVALCGQLMGTSYFLKDCFFN-PRILALQNGKFV 97
            |:||...:..|.|...:.:.||:|......|:..|||||.|....|.|.... |.::.::|.||.
Mouse    19 FLYDGSKVKGEGDPTRAGICYFYPPQTLLDQQELLCGQLAGVVRCLWDLSGTPPMLIRMRNLKFA 83

  Fly    98 LKEFGRFILAIGTDRNIGDQLLEHRADLLSSLLKFFHRDVQTLYAQYAAPPALNRRNLSEKLYHI 162
            ::..|.::.|:|....|.|....   ..|..|:.|||..:..:...|.:.|       .|:|...
Mouse    84 IRADGDYLWALGCGVEISDASCR---QFLDQLIGFFHFYMGPVSLAYKSHP-------QEELSLQ 138

  Fly   163 FETYLPMLQRNG-------NTFQNVPRLRMPKTASHIFLEAIQTLQSCQQTKGILGGAILYHNKV 220
            ::|.:..:.|:.       |...|:.|   .|....:.|:|...||:||::..:|.|.|||...:
Mouse   139 WDTSITQVLRSTSESHRIFNALWNLDR---TKVEPLLLLKAALILQTCQRSPHVLAGCILYKGLI 200

  Fly   221 VASQLSDMVTKHLVL--TDPLHIRT----AAEQVTNHPEFHIPNGVQMLVVYLEHMQYRQLAGEA 279
            |.|||...:|..::|  |.|...|.    ||.|.|...   :|..||:..|:|...:...|
Mouse   201 VNSQLLPSLTAKVLLHQTVPADQRLPGAGAAPQETGAA---LPPDVQITSVFLSEEEVASL---- 258

  Fly   280 QRAQNLQMNTAQLTQNGMPFQYAKRKIKRDKSLIFTHIPEEEHAPEQQGAVEQLPPARPKSMRPT 344
                                                |....||....||:..|.||....|  ||
Mouse   259 ------------------------------------HEFPVEHETRLQGSSVQYPPWDQSS--PT 285

  Fly   345 HLPLRIKSMQSKELPESGIASINFDETDSYPQFIGRTSVCNTPMTENKVLPVANVMSICANPEDE 409
            .             .|...||.      :.|:.......|.:....::.||  .:...||.|.
Mouse   286 Q-------------AEDAWASA------AIPEPTPHDGACPSGSGADERLP--RLEQECAGPT-- 327

  Fly   410 GKEEDIHNSNGKTHSRRNSLKVDVEKFFQNFISNPNKQLTRRKSSADLQDALRAISKKLNNFTHG 474
                                                                            |
Mouse   328 ----------------------------------------------------------------G 328

  Fly   475 LKTDVNRNGSGNGDVSSDSPDFIEDDDKITSRTISDPTYPVFNTNGQQISRSLFQQFLDQYRKLW 539
            |.|.....|||                 ::||.              |....|.::.||
Mouse   329 LCTTACGQGSG-----------------LSSRL--------------QKELCLSREELD------ 356

  Fly   540 GVASEQAHEDAELAALVAEFQEFNAEIQKL-DEHMRQQAAEASSADRNLNVSAAKTPLDKRSMTL 603
               |.:.|        |:|.||....:..| |......:..|.:...:..:.:...|       .
Mouse   357 ---SSEMH--------VSEAQEAFPPLPALGDLETLHSSHSAPTLPEDTAICSCLHP-------C 403

  Fly   604 PLKSAGESTFGERASGRSG-AGGVPLT----------PLMAKLSVLALSETTPIEIQTPLTTSKV 657
            ||:...|       |||.| ...:|||          ||.:.:.| ||....|:.::     ..|
Mouse   404 PLERLPE-------SGRLGQLADLPLTNGQTQVPGTDPLPSSMPV-ALPPQHPVGVE-----PSV 455

  Fly   658 FPRRSSLKCEDAVDALAALTTAPAQP-PGP------IQPD------GLQRTELYICGQQNMTLLL 709
            .|..:.  .:::..||...:.:|..| |.|      .:|.      ||....||......:.|.|
Mouse   456 EPYGNG--AQESHSALPRSSRSPDSPGPSPSADRTGFKPSPSGRHAGLVPMNLYTHSVNGLVLSL 518

  Fly   710 LMEEGTCQQQQVVQKMFDICVAKFPHMESQLNQTLNVNVEGDNRD-----GSNYSFMCVDSKWDV 769
            |.||........:::::...:|....:|..|.:||       .||     .|.|:|:..|....|
Mouse   519 LAEETLLSDTAAIEEVYHSSLASLNGLEVHLKETL-------PRDEASLTSSTYNFLHYDRIQSV 576

  Fly   770 LQRNGP--WNPLELNILESMHSIHSSG---HHLTDLILRSNDSVYYGHKNGRTEFFYKE--PTHQ 827
            |..|.|  ..|.:...|::::.:||..   ..|.::.:|:..:..|...:...|.::::  ||.:
Mouse   577 LSANLPLVTAPQDRRFLQAVNLMHSDFALLPMLYEMTIRNASTAVYACSSPAQETYFQQLAPTAR 641

  Fly   828 INGIPPPSDPIGNIQSRAKSRL 849
            .:|.|.|.|...::..:||.:|
Mouse   642 SSGFPNPQDCAFSLAGKAKQKL 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPS4	NP_611246.1	Intu_longin_1	31..135	CDD:436911	30/101 (30%)
		Intu_longin_3	754..848	CDD:436913	25/105 (24%)
Hps4	NP_619587.3	Intu_longin_1	15..121	CDD:436911	31/104 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	269..291		9/36 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	417..497		18/87 (21%)
		Intu_longin_3	561..662	CDD:436913	24/100 (24%)