Protein Alignment Sema1b and SEMA3E

DIOPT Version :9

• Sequence 1: NP_001163178.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: NP_036563.1
• Gene: SEMA3E / 9723
• HGNCID: 10727
• Length: 775
• Species: Homo sapiens
• Alignment Length: 621
• Identity: 186/621 - (29%)
• Similarity: 295/621 - (47%)
• Gaps: 86/621 - (13%)

  Fly    63 ILDHNDEFVLVGAKDVIYNVSL----NGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYA 123
            :||...|.:.||.:|::|::||    :|.|||   .|.||....|.|.:|||...:|.||:||..
Human    62 LLDEYQERLFVGGRDLVYSLSLERISDGYKEI---HWPSTALKMEECIMKGKDAGECANYVRVLH 123

  Fly   124 LRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTY 188
            ......:|.|||.::.|.|..   :.|.........|..:.|.|..|     |.||:.|:.:...
Human   124 HYNRTHLLTCGTGAFDPVCAF---IRVGYHLEDPLFHLESPRSERGR-----GRCPFDPSSSFIS 180

  Fly   189 AFADGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAI-------ERNGYVL 241
            ......|::...:|:...|..|:|.     ::|||..|.:.|.:|.|||:.       ..:..|.
Human   181 TLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVY 245

  Fly   242 FFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPG--EFPFYFDEIQ 304
            |||.|.::|..|...|:|:||.|:|.||.||.......|::||||||.|||||  ....||||::
Human   246 FFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELE 310

  Fly   305 AISPIVESGSKS-LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQV 368
            .:..:.....|: :|:.:|.|:.|...|.|:|.:::..|.|||:|.:..::..:.|| .|...:|
Human   311 DVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHW-SVYEGKV 374

  Fly   369 PKPRPGQCVE--------DSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVH 425
            |.||||.|..        .::.....|:.|.::||||.:|:...|.:|:|.|.:..:.|..|||
Human   375 PYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAV- 438

  Fly   426 PQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVIST 490
            .:|::..| .|||::.|||:|.|.|.|.|.    |..::.::.|::.|:|:.....||..:.||:
Human   439 DRVEAEDG-QYDVLFIGTDNGIVLKVITIY----NQEMESMEEVILEELQIFKDPVPIISMEISS 498

  Fly   491 SKNSLVVVSDGSLVSVPLHHC----SHIVDCLGCLSLQDPICAWD---------LQTH------- 535
            .:..|.:.|..::..|..|||    |...||  ||: :||.||||         ..||
Human   499 KRQQLYIGSASAVAQVRFHHCDMYGSACADC--CLA-RDPYCAWDGISCSRYYPTGTHAKRRFRR 560

  Fly   536 -ECKNLATSQHKFGTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSN 599
             :.::...:|..||.:....:|:.|::       |:   |.|.|..|.:....|.:.:.|:::.
Human   561 QDVRHGNAAQQCFGQQFVGDALDKTEE-------HL---AYGIENNSTLLECTPRSLQAKVIWF- 614

  Fly   600 VGSSQGNQPSLEQQPTGGD----DFGLNKITLTSMD 631
              ..:|.:...|:..|...    |.||..:.|...|
Human   615 --VQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSD 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	151/474 (32%)
		PSI	510..>537	CDD:214655	15/47 (32%)
SEMA3E	NP_036563.1	Sema_3E	49..519	CDD:200514	151/474 (32%)
		PSI	518..566	CDD:214655	15/50 (30%)
		Ig_Semaphorin_classIII	585..670	CDD:143279	16/77 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	742..775

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010