Protein Alignment Sema1b and SEMA5A

DIOPT Version :9

• Sequence 1: NP_001163178.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: NP_003957.2
• Gene: SEMA5A / 9037
• HGNCID: 10736
• Length: 1074
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 186/529 - (35%)
• Similarity: 271/529 - (51%)
• Gaps: 65/529 - (12%)

  Fly    56 NSTDYFKI-LDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEWDCHNYL 119
            |:.|:.:: .|...:.::|||::.::.:.|..|..|..:||...:|.::.|..|||.:.:|.||:
Human    54 NAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYI 118

  Fly   120 RVYALRPNGEVLL-CGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPA 183
            ||  |...|:.|. ||||::.|.|.:.:...::               |:...:.....|||||.
Human   119 RV--LLVGGDRLFTCGTNAFTPVCTNRSLSNLT---------------EIHDQISGMARCPYSPQ 166

  Fly   184 HNSTYAF-ADGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLF 242
            ||||... |.|.||:||..||.|.||.|||.     .|||.||:.|.||:|:||.:.:...:..|
Human   167 HNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYF 231

  Fly   243 FFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAIS 307
            ||||.::| .:.||.|:||.|||||||.||.:....:||:|:|||||||.|||.|||::|:|:..
Human   232 FFRENAVE-HDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTF 295

  Fly   308 PIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPR 372
            .:.|   ..|||.:|||:||:|..||||.||:..|..||.|.||.|::|:|.|||     .|.|.
Human   296 FLPE---LDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLP-----YPNPN 352

  Fly   373 PG-QC--VEDSR--TLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLS 432
            |. ||  |:...  .||...:...:...||.|.|..|...|...:.|  .|.:.:||  .|....
Human   353 PHFQCGTVDQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDN--SRFSHVAV--DVVQGR 413

  Fly   433 GAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLP--LGTPIRELVISTSKNSL 495
            .|...:||..||.|.:.| :.:.....:|      :.::.|:::.|  ...|||.|.|..|::.|
Human   414 EALVHIIYLATDYGTIKK-VRVPLNQTSS------SCLLEEIELFPERRREPIRSLQILHSQSVL 471

  Fly   496 VVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSLNSTK 560
            .|.....:|.:||..|........|:..|||.|.||:...:|.:|.            :||:.|:
Human   472 FVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLE------------ESLSMTQ 524

  Fly   561 -KAAALLCP 568
             :.:...||
Human   525 WEQSISACP 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	171/469 (36%)
		PSI	510..>537	CDD:214655	8/26 (31%)
SEMA5A	NP_003957.2	Sema_5A	50..485	CDD:200524	170/467 (36%)
		PSI	486..533	CDD:279745	13/58 (22%)
		TSP1	544..595	CDD:214559
		TSP1	598..651	CDD:214559
		TSP1	656..702	CDD:214559
		TSP1	787..839	CDD:214559
		TSP1	844..896	CDD:214559
		TSP1	899..940	CDD:214559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810