DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema1b and SEMA7A

DIOPT Version :10

Sequence 1:NP_611244.1 Gene:Sema1b / 37007 FlyBaseID:FBgn0016059 Length:770 Species:Drosophila melanogaster
Sequence 2:NP_003603.1 Gene:SEMA7A / 8482 HGNCID:10741 Length:666 Species:Homo sapiens


Alignment Length:662 Identity:167/662 - (25%)
Similarity:267/662 - (40%) Gaps:149/662 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 PSSAAMLVNAIPMILLITL------------SGLTIVAGWMPDVKPDL----QTKQDKVLAHFIG 55
            |...|.|...:.:.||:.|            ||..|.|.|...|..|.    ||:...||.|..|
Human    19 PGPPARLGLPLRLRLLLLLWAAAASAQGHLRSGPRIFAVWKGHVGQDRVDFGQTEPHTVLFHEPG 83

  Fly    56 NSTDYFKILDHNDEFVLVGAKDVIY--------NVSLNGLKEIARLEWHSTDADRELCALKGK-- 110
            :|:            |.||.:..:|        |.|:..:               .:.:.||.  
Human    84 SSS------------VWVGGRGKVYLFDFPEGKNASVRTV---------------NIGSTKGSCL 121

  Fly   111 HEWDCHNYLRVYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQ 175
            .:.||.||:.:...|..| :|.||||:..|.|  :..|..:....|                |.:
Human   122 DKRDCENYITLLERRSEG-LLACGTNARHPSC--WNLVNGTVVPLG----------------EMR 167

  Fly   176 GLCPYSPAHNSTYAFADGHLYSATV--ADFSGGDPLIYRENLRTEQYDLKQLNQ-PDFVGAI--- 234
            |..|:||..||...|....:|| |:  .:::|..|...|....:|.|....:.| |.|:.|.   
Human   168 GYAPFSPDENSLVLFEGDEVYS-TIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVH 231

  Fly   235 ERNGY---VLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKS-WTSFLKARLNCSVPGE 295
            :...|   :.:||||.:.:.........||||::|:.|:||..|...| |.:||||.|.|| ...
Human   232 QDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCS-DAA 295

  Fly   296 FPFYFDEIQAISPIVESGSK---SLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQ 357
            ....|:.:|.:..:.:...:   :.:|.||:...|.   ||||.:::.||    |..|::.....
Human   296 TNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY---SAVCVYSLGDI----DKVFRTSSLKG 353

  Fly   358 SHWLPVEREQVPKPRPGQCVEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKV---NLHHRL 419
            .|      ..:|.||||:|:.|.:.:.:........||.:.:.|..:  .||.|.:   ..|:: 
Human   354 YH------SSLPNPRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPM--GPLKTPLFHSKYHYQ- 409

  Fly   420 TAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPL--GTP 482
             .:||| ::::..|..:.|:|..||.|.:.|.:     .|.   ::..:...:.|::.|.  ...
Human   410 -KVAVH-RMQASHGETFHVLYLTTDRGTIHKVV-----EPG---EQEHSFAFNIMEIQPFRRAAA 464

  Fly   483 IRELVISTSKNSLVVVSDGSLVSVPLHHCS-HIVDCLGCLSLQDPICAWDLQTHECKNLATSQHK 546
            |:.:.:...:..|.|.|...:..|||..|. :...|.|||..:||.|.||  ...|.::.:|:  
Human   465 IQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWD--QGRCISIYSSE-- 525

  Fly   547 FGTKTYLQSLNSTKKAAALLCPH--IPRDAPGAETVSFVTMAPP-------PTEEQKLLYS---- 598
               ::.|||:|..:       ||  .|...|....:..|::||.       |.|.:...||    
Human   526 ---RSVLQSINPAE-------PHKECPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHK 580

  Fly   599 -NVGSS--QGNQ 607
             ||..|  .|:|
Human   581 ENVEQSCEPGHQ 592

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema1bNP_611244.1 Sema_1A 55..511 CDD:200498 117/483 (24%)
PSI 510..>537 CDD:214655 10/27 (37%)
SEMA7ANP_003603.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 1/1 (100%)
Sema_7A 72..491 CDD:200504 120/492 (24%)
Cell attachment site. /evidence=ECO:0000255 267..269 0/1 (0%)
Interaction with integrins 267..269 0/1 (0%)
PSI 493..>520 CDD:396154 11/28 (39%)
Ig 549..619 CDD:472250 12/44 (27%)
Ig strand B 562..566 CDD:409456 0/3 (0%)
Ig strand C 574..578 CDD:409456 2/3 (67%)
Ig strand E 596..600 CDD:409456
Ig strand F 610..615 CDD:409456
Blue background indicates that the domain is not in the aligned region.

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