Protein Alignment Sema1b and Sema6b

DIOPT Version :9

• Sequence 1: NP_001163178.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: XP_006244410.1
• Gene: Sema6b / 84609
• RGDID: 69278
• Length: 957
• Species: Rattus norvegicus
• Alignment Length: 708
• Identity: 217/708 - (30%)
• Similarity: 325/708 - (45%)
• Gaps: 138/708 - (19%)

  Fly    18 PMILLITLSGLTIVAGWMPDVKPDLQTKQDKVLAH---FIGNS----TDYFKILDHNDEFVL--- 72
            |.:|.:.|..|.:..|..||..|.|.......|:|   |:|:.    |......|.|.:.||
  Rat    81 PALLFLLLLLLRVTHGLFPDEPPPLSVAPRDYLSHYPVFVGSGPGRLTPAEGAEDLNIQRVLRVN 145

  Fly    73 ----VGAKDVIYNVSL-----NGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNG 128
                :|.:|.:|.|.|     ..|:...:|.|.|..:|.::|.:|||.|.:|.|:::|..||...
  Rat   146 RTLFIGDRDNLYQVELEPSTSTELRYQRKLTWRSNPSDIDVCRMKGKQEGECRNFVKVLLLRDES 210

  Fly   129 EVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADG 193
            .:.:||:|::.|.|.:|     |.:.....|.          ::.....|||.|.|.:...|:||
  Rat   211 TLFVCGSNAFNPICANY-----SMDTLQLLGD----------NISGMARCPYDPKHANVALFSDG 260

  Fly   194 HLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMN 253
            .|::|||.||...|.:|||.     .|||.::|.|...:|.||.|:|...:|.|||||::||...
  Rat   261 MLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNY 325

  Fly   254 FGKAVYSRVARVCKNDRGG-PYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVESGSKSL 317
            ..|.|.||||||||||.|| |....|.|||||||||||||||:..|||:.:||::.:|..|.:.:
  Rat   326 LEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGRPV 390

  Fly   318 IYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCV----- 377
            |.|||:|..|:|||||||||:::.:.|.|:|.|:.||..:|.|.||..:|||:||||.|.
  Rat   391 ILAVFSTPSNSIPGSAVCAFDMNQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQ 455

  Fly   378 -EDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYDVIYS 441
             ..|..|....:||:|.||||:||||::...|.:.:..:.|:||.:||  .|.:.......:::.
  Rat   456 YNASNALPDEILNFVKTHPLMDEAVPSLGHSPWIVRTLIRHQLTRVAV--DVGAGPWGNQTIVFL 518

  Fly   442 GTDDGKVTKFINILSTHPNSTVDRL--KTVVISEMQVL------------PLGTPIRELVISTSK 492
            |::.|.|.||:    ..||::|...  .::.:.|.:..            ..|..:..|.:..:.
  Rat   519 GSEVGTVLKFL----VKPNASVSGTTGPSIFLEEFETYRPDRCGRSSSAGEWGQRLLSLELDAAS 579

  Fly   493 NSLVVVSDGSLVSVPLHHCSHIVDCL-GCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSL 556
            ..|:......:|.||:..|.....|: .|:..|||.|.|
  Rat   580 GGLLAAFPRCVVRVPVARCQLYSGCMKNCIGSQDPYCGW-------------------------- 618

  Fly   557 NSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQGNQPSLEQQPTGGDDFG 621
                             ||..   |.:.:.|                 |...:.||..:|....|
  Rat   619 -----------------APDG---SCIFLRP-----------------GTSATFEQDVSGASTSG 646

  Fly   622 LNKITLTSMDPDDIMPNLNDPQKSTASVDEIKYASTPSFMLLTTIVFFTFLVGGIAGI 679
            |...|      ..:..:|:|.:....||:.:..:|..:|::...:..|:  ||...|:
  Rat   647 LGDCT------GLLRASLSDDRAGLVSVNLLVTSSVAAFVVGAVVSGFS--VGWFVGL 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	176/497 (35%)
		PSI	510..>537	CDD:214655	8/27 (30%)
Sema6b	XP_006244410.1	Sema_6B	128..596	CDD:200528	175/488 (36%)
		PSI	597..>626	CDD:279745	11/74 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1206
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2014
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8939
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860