DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema1b and SEMA6D

DIOPT Version :9

Sequence 1:NP_001163178.1 Gene:Sema1b / 37007 FlyBaseID:FBgn0016059 Length:770 Species:Drosophila melanogaster
Sequence 2:NP_001345281.1 Gene:SEMA6D / 80031 HGNCID:16770 Length:1086 Species:Homo sapiens


Alignment Length:800 Identity:256/800 - (32%)
Similarity:377/800 - (47%) Gaps:134/800 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 ILLITLSGLTIVAGWMPDVKPDLQTKQDKVLAHF-----------IGNST----DYFKILDHNDE 69
            |||:.:|.|..|:  .|:....|.|    |..|:           .||.:    |:..:|...|.
Human    10 ILLLMVSQLRAVS--FPEDDEPLNT----VDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDT 68

  Fly    70 FVLVGAKDVIYNVSLNGLKEI-----ARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGE 129
            ..:.| :|.:|.|:||.:.:.     .:|.|.|...|||.||:||||:.:|||:::|:..|.:..
Human    69 LYIAG-RDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEM 132

  Fly   130 VLLCGTNSYKPRCRHY--TPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFAD 192
            |.:||||::.|.||:|  :.:|...||                 :.....||:.....:...|||
Human   133 VFVCGTNAFNPMCRYYRLSTLEYDGEE-----------------ISGLARCPFDARQTNVALFAD 180

  Fly   193 GHLYSATVADFSGGDPLIYR-----ENLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVM 252
            |.|||||||||...|.:|||     ..|||.:||.|.:.:|.|:.|||...||.|||||:::|..
Human   181 GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHN 245

  Fly   253 NFGKAVYSRVARVCKNDRGGPYS-HGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVESGSKS 316
            |.||||||||||:||||.||... ..|.|||||||||||||||:..||||.:|:|:.|::.....
Human   246 NLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIP 310

  Fly   317 LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCVEDSR 381
            .:..||||.:|:|||||||||::|||...|.|.||.||...|.|..|..::|||||||.|.:...
Human   311 TVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGL 375

  Fly   382 T---LTSI-----AVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAY--Y 436
            .   .|||     .::|||:||||:.|||.:...|..||..:.:|||||:|...    :|.|  |
Human   376 AEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHS----AGPYQNY 436

  Fly   437 DVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVL---------PLGTPIRELVISTSK 492
            .||:.|::.|.|.|.  :..|.|.|..|   :|::.|::..         .....:..|.:....
Human   437 TVIFVGSEAGMVLKV--LAKTSPFSLND---SVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDH 496

  Fly   493 NSLVVVSDGSLVSVPLHHCSHIVDC-LGCLSLQDPICAWDLQTHECKNLATSQ----------HK 546
            ::|.|.....::.:||..|.....| ..|::.:||.|.| |....|..:....          |.
Human   497 HALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGW-LSQGSCGRVTPGMLLLTEDFFAFHN 560

  Fly   547 FGTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQGNQPSLE 611
            ...:.|.|.......|....|..|   .|.:.|..:.... .||.:.::..|:| ::..:.|.:.
Human   561 HSAEGYEQDTEFGNTAHLGDCHEI---LPTSTTPDYKIFG-GPTSDMEVSSSSV-TTMASIPEIT 620

  Fly   612 QQPTGGDDFGLNKITLTS--MDPDDIMPNLNDPQKSTASVD-----EIKYASTPSFM---LLTTI 666
            .:..   |....|:|.:.  :..||  ||.:|.....:.:.     |::...:...:   :|.|.
Human   621 PKVI---DTWRPKLTSSRKFVVQDD--PNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLITC 680

  Fly   667 VFFTFLVGG-IAGIC--CVK----AKSRLMEAQMDESH------------RNHFGKPMQFKHQNT 712
            ||..|::|. |||:.  |.:    .|:|.:....:.:.            ...|..|::...||.
Human   681 VFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNI 745

  Fly   713 GKDINLLMGSNAYTTTQKTP 732
            ...   .:.||..|:.::.|
Human   746 DSP---KLYSNLLTSRKELP 762

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema1bNP_001163178.1 Sema_1A 55..511 CDD:200498 194/491 (40%)
PSI 510..>537 CDD:214655 8/27 (30%)
SEMA6DNP_001345281.1 Sema_6D 49..513 CDD:200530 193/490 (39%)
PSI 514..>543 CDD:307546 9/29 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..788 0/5 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..838
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 852..887
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 927..1018
Herpes_BLLF1 944..>1080 CDD:330317
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1034..1086
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 318 1.000 Domainoid score I1252
eggNOG 1 0.900 - - E1_KOG3611
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 373 1.000 Inparanoid score I2116
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000892
OrthoInspector 1 1.000 - - mtm8465
orthoMCL 1 0.900 - - OOG6_101616
Panther 1 1.100 - - O PTHR11036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X415
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.820

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