DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and LOC798168

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_009290884.1	Gene:	LOC798168 / 798168	-ID:	-	Length:	739	Species:	Danio rerio

Alignment Length:	705	Identity:	182/705 - (25%)
Similarity:	294/705 - (41%)	Gaps:	157/705 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ILDHNDEFVLVGAKDVIYNVSLNGLKEIA---RLEWHSTDADRELCALKGKHEWDCHNYLRVYAL 124
            :|..:::.:.|||:|.::::.::....|.   .|:|..:....:.|.:..|  .||.|::.:...
Zfish    55 LLSTDEDTLFVGARDALFSLDVSQSDSITLKDELKWTPSSDQTKTCRVASK--LDCGNFISILQF 117

  Fly   125 RPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYA 189
            ..:..:..||||:|||:.   ..:..||..|           .:.:. :|:..||:|....:|..
Zfish   118 FNSTHLYACGTNAYKPQA---IIIPASSLNA-----------NIDKK-DAKNCCPFSSTQRNTAI 167

  Fly   190 FADGHLYSATVADFSGGDPLIYR-------ENLRTEQYDLKQLNQPDFVGA--IERNGYVLFFFR 245
            ..||.||:||...|.|...:|.|       .||..|... |.|.:|.|:.:  :...|.:|.||.
Zfish   168 IVDGELYTATNVGFFGDKNVISRCHSRGTHNNLELETVP-KLLQEPVFISSTHVASEGKILLFFT 231

  Fly   246 E---LSMEVMNFGKA-VYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAI 306
            |   ||.:.  ||.: ..||||:||.:|.||..:..:.||||.||:|.|. .|| ...|:::|.|
Zfish   232 ENGDLSGDY--FGNSFTVSRVAQVCTDDNGGTLTLQRRWTSFAKAQLVCQ-QGE-DLQFNKLQDI 292

  Fly   307 SPIVESGS----KSLIYAVFTTSVNAIPG-SAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVERE 366
            ..:..|.|    |:|.|.|||:..:...| ||||||::.||.|||.|.:|:.....:||
Zfish   293 VKLSPSDSDSPDKTLFYGVFTSQRSVSSGLSAVCAFSLTDIKAAFSGNYKTFDLRGNHW------ 351

  Fly   367 QVPKPRP------GQC--VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIA 423
               .|:|      |:|  ..|    |...:|.:|...|.|..|..:....||:  :...:.|.:|
Zfish   352 ---SPQPNTDGKLGKCGLFND----TDSVLNRVKKSFLTENVVHPMDKTLLLS--SAEEQYTRLA 407

  Fly   424 VHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVI 488
            || :.:::.|..|.::|..|:.|.:.|.: :|:..|:         :|.|:|:.......:.:::
Zfish   408 VH-RAQAVDGQTYTILYLLTESGFLHKVV-LLAEGPH---------IIEEIQIFKQPQIAKNILL 461

  Fly   489 STSKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYL 553
            |.||:.|.:.|...:..|||.:||...:|..|:..:||.||||.:|..|  .|.|:.|...:..:
Zfish   462 SKSKSVLFIGSSEGVFRVPLSNCSAYPNCAECVLARDPFCAWDTETRAC--TAVSETKSTLRQDV 524

  Fly   554 QSLNST------KKAAALL-------------CPHIPRDAPGAETVSFVTMAP------------ 587
            :..|.|      :..||:|             |....:.|......|..::.|
Zfish   525 ERGNVTEQCIEFRNTAAVLFKTAHLNEIVVLPCQSKSKLAKMTWRFSNNSLVPQFPYLQWTDGSL 589

  Fly   588 --PPTEEQKLLYSNVGSSQGNQPSL------------------EQQPTGGDDFGLNKITLTSMDP 632
              |.:.|....|..|....|.|.::                  .|||        ..|..|:::.
Zfish   590 VFPVSLETTNTYRCVSEELGFQQTIATFSVNLPVVPRSRMSPSHQQP--------EHIDFTTIEL 646

  Fly   633 DDIMP----------------NLNDPQKSTASVDEIKYASTPSFMLLTTIVFFTF 671
            |:..|                ..:|..|.|..:.:..|.|.   |:...|.|..|
Zfish   647 DESEPINEEKINDRSEEKQASTYHDAGKDTLCISQKSYYSE---MVAVCIFFVIF 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	136/476 (29%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	11/26 (42%)
LOC798168	XP_009290884.1	Sema_4	43..482	CDD:200501	135/474 (28%)
		PSI	483..527	CDD:214655	15/45 (33%)
		Ig_Sema4B_like	540..624	CDD:143280	13/83 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010