DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and sema4e

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001077334.1	Gene:	sema4e / 796377	ZFINID:	ZDB-GENE-990715-7	Length:	766	Species:	Danio rerio

Alignment Length:	760	Identity:	211/760 - (27%)
Similarity:	336/760 - (44%)	Gaps:	133/760 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 DYFKILDHND-EFVLVGAKDVIYNVSLNGLK-EIARLEWHSTDADRELCALKGKHEW-DCHNYLR 120
            :|..:|..:| ..:::||::.|:.:.|:.:. :.|.|:|..|...:..|:.|||... ||.||:|
Zfish    52 NYTTMLLRDDLNLLILGAREAIFALDLDDITIKKAMLKWEVTRDQQNDCSNKGKDATNDCKNYIR 116

  Fly   121 VYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHA-MRYEVSRDVEAQGLCPYSPAH 184
            :...:.:|.:.:|||.::.|.|             |...:|.. :..|:.:: :.:|.||:.|..
Zfish   117 ILHKKDDGRMYVCGTKAFNPTC-------------GYLSYADGKLTLEILQE-DTKGKCPFDPFQ 167

  Fly   185 NSTYAFADGHLYSATVADFSGGDPLIYR---ENLRTEQYDLKQLNQPDFV-------GAIERNG- 238
            ..|.|..||..||||..:|.|.:|::.|   |::||| :....|::|:|:       |....:|
Zfish   168 RYTSAMVDGAYYSATSMNFRGSEPVMMRSTEESIRTE-FTSTWLSEPNFIHMAHIPEGQSNPDGD 231

  Fly   239 --YVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPG-EFPFYF 300
              .:..||.|.::|..:..|...||||||||.|.||..:..|.|||||||||:|.||. ..|...
Zfish   232 DDKIYLFFSETAVEYESCTKVDVSRVARVCKGDLGGQRTLQKKWTSFLKARLDCQVPNTNLPLLV 296

  Fly   301 DEIQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFD-GEFKSQ---KDSQSHWL 361
            .::..:.|  :..:..:.|||||...::...||||::.::||...|. |:||:.   :.|...|:
Zfish   297 QDVFHLCP--DDWTTCVFYAVFTPQSDSSQYSAVCSYKIEDIKTVFSKGKFKAPFNVETSFVKWV 359

  Fly   362 PVEREQVPKPRPGQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHH 417
            ....| :|.||||.|:::         |..|....:.|:|:.|||::||.|  .:|||.|...
Zfish   360 MYSGE-LPDPRPGACIDNHARQKGITKSLELPDKTLQFVKDKPLMDQAVTA--EQPLLVKRGA-- 419

  Fly   418 RLTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTP 482
            ..|.|.| ....:|:|..:.|::.||..|.|.|.:|...          :.|::.|:|:.....|
Zfish   420 AFTRIVV-TTATALNGTSHQVMFIGTKSGSVLKAVNYNG----------EMVIMEEIQLFEPSEP 473

  Fly   483 IRELVISTSKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKF 547
            |:.|.:|:||..|.|.|:..:|.:.:..|.....||.|:..:||.|.|||.|..|..: .|.|:.
Zfish   474 IKILRLSSSKKQLYVGSEVGVVQLSISECGQYQTCLDCVLARDPHCGWDLDTEHCATI-NSIHRT 537

  Fly   548 GTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVSF-----VTMAPPPTEEQKLLYSNVGSSQGNQ 607
            .:.|.:|||:.   ..|..||.|....|  ..:||     |.:...|       |||:.
Zfish   538 RSSTVIQSLSD---GDASQCPAIGVSKP--VNISFYHGNTVKLGCQP-------YSNLA------ 584

  Fly   608 PSLEQQPTGGDDFGLNKITLTSMDPDDIMPNLNDPQKSTASVDEIKYASTPSFMLLTTIVFFTFL 672
             .:|.|..|......|.|.:.|   |.:|       ...||:|...|....|...::...:.|..
Zfish   585 -QVEWQLNGEPIKPSNTIQILS---DGLM-------IFNASLDATGYYICSSIETVSQRKYQTQH 638

  Fly   673 V----------GGIAGICCVKAKSRLMEAQMD------------ESHRNHFGKP--------MQF 707
            |          |..|.:..||.|.|.:.|.:.            ..::.|...|        .|.
Zfish   639 VAYDVKMWSESGTTASLHHVKEKERTLVAMVVILSLVLAALLIWNLYKGHLSLPCLHRRVKDTQN 703

  Fly   708 KHQNTGKDINLLMGSN-AYTTTQKTPNLDLEKDRSHECKNSTEHL 751
            :|::   |.|.:.... |.:......|.:...|:.:.....|:.|
Zfish   704 RHED---DANQVQPQRLASSVVNFNSNNNHANDQRYSSSRETDRL 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	148/482 (31%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	11/26 (42%)
sema4e	NP_001077334.1	Sema_4E	45..500	CDD:200521	148/480 (31%)
		PSI	501..555	CDD:214655	19/57 (33%)
		Ig	567..640	CDD:299845	20/96 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	724..750		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910