Protein Alignment Sema1b and SEMA3B

DIOPT Version :9

• Sequence 1: NP_001163178.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: NP_001276990.1
• Gene: SEMA3B / 7869
• HGNCID: 10724
• Length: 754
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 171/561 - (30%)
• Similarity: 271/561 - (48%)
• Gaps: 56/561 - (9%)

  Fly     6 RPSSAAMLVNAIPMILLITLSGLTIVAGWMPDVKPDLQTKQD-KVLAHFIGNSTDYFK--ILDHN 67
            |..:||:    ||.:.|:...||...|...|.::...|..|. ..|..|....|..::  ::|..
Human     3 RAGAAAV----IPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEE 63

  Fly    68 DEFVLVGAKDVIYNVSLNGL-KEIARLEWHSTDADRELCALKGKH-EWDCHNYLRVYALRPNGEV 130
            ...:.|||::.:.:::|:.: |...:|.|.:....||.|...||. ..:|.|::::........:
Human    64 RGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHL 128

  Fly   131 LLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHL 195
            |.|||.::.|.|        :..|.|.......:|.:..|..:.:|..||.|.|.:........|
Human   129 LACGTGAFHPTC--------AFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEEL 185

  Fly   196 YSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAI-------ERNGYVLFFFRELS 248
            ||...||..|.|..|:|.     :||||.:|.:.||:|.||...       ..:..:.|||||.:
Human   186 YSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETA 250

  Fly   249 MEVM-NFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPG-EFPFYFDEIQAI--SPI 309
            :|.. ..|:...|||.::|:||.||..|....||:||||||.||||| |...:||:::..  ..:
Human   251 VEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLRPFPAEDV 315

  Fly   310 VESGSKS----LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPK 370
            ....|:.    |:||||:||.:...|||||.::::|:..||.|.|..::.....|:..: .:||.
Human   316 FLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQ-GRVPY 379

  Fly   371 PRPGQCVEDSRTLTSIA---------VNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHP 426
            ||||.|  .|:|..:.:         :.|.:|||||..:|....||||..:|..::..|.||. .
Human   380 PRPGMC--PSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAA-D 441

  Fly   427 QVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTS 491
            :|.:..| :|||::.|||.|.|.|.|::    |..:....:.:::.|:.|......:..:.||:.
Human   442 RVAAADG-HYDVLFIGTDVGTVLKVISV----PKGSRPSAEGLLLEELHVFEDSAAVTSMQISSK 501

  Fly   492 KNSLVVVSDGSLVSVPLHHC-SHIVDCLGCLSLQDPICAWD 531
            ::.|.|.|..::..:.||.| :|...|..|...:||.||||
Human   502 RHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWD 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	147/488 (30%)
		PSI	510..>537	CDD:214655	10/23 (43%)
SEMA3B	NP_001276990.1	Sema	46..521	CDD:301699	148/491 (30%)
		PSI	520..>556	CDD:214655	10/23 (43%)
		Ig_Semaphorin_classIII	580..670	CDD:143279
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	707..754

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910