DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema1b and SEMA4A

DIOPT Version :9

Sequence 1:NP_001163178.1 Gene:Sema1b / 37007 FlyBaseID:FBgn0016059 Length:770 Species:Drosophila melanogaster
Sequence 2:NP_001180229.1 Gene:SEMA4A / 64218 HGNCID:10729 Length:761 Species:Homo sapiens


Alignment Length:776 Identity:208/776 - (26%)
Similarity:322/776 - (41%) Gaps:176/776 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 ILDHNDEFVLVGAKDVIYNVSLN--GLKEIAR-LEWHSTDADRELCALKGK-HEWDCHNYLRVYA 123
            :|..:...:.|||::.|..:.:.  |:..:.. :.|.::|..:..||.|.| :|..|.|::||..
Human    68 LLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLV 132

  Fly   124 LRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTY 188
            ......:..|||.::.|.|   |.:|:..        ::.:.....:.:|.:|..|:.|||..|.
Human   133 SYNVTHLYTCGTFAFSPAC---TFIELQD--------SYLLPISEDKVMEGKGQSPFDPAHKHTA 186

  Fly   189 AFADGHLYSATVADFSGGDPLIYR-----ENLRTEQYDLKQL-NQPDFVGAIERNGYVLFFFREL 247
            ...||.|||.|:.:|.|.:|::.|     ..|:|:.: |:.| :...||.||.....|.|||.|.
Human   187 VLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNF-LRWLHHDASFVAAIPSTQVVYFFFEET 250

  Fly   248 SMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVES 312
            :.|...|.:...||||||||||.||.....|.||:||||:|.|:.||:.||.......:.| .:|
Human   251 ASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQLPFNVIRHAVLLP-ADS 314

  Fly   313 GSKSLIYAVFTT--SVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQ 375
            .:...||||||:  .|.....||||||::.||...|.|::|......|.| ...|.....||||.
Human   315 PTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRW-TTYRGPETNPRPGS 378

  Fly   376 C-VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYDVI 439
            | |..|   :..|:.|:|:|.||:|.|.   |.|||.|..:.:  |.:||. ..:.|.|..:.|:
Human   379 CSVGPS---SDKALTFMKDHFLMDEQVV---GTPLLVKSGVEY--TRLAVE-TAQGLDGHSHLVM 434

  Fly   440 YSGTDDGKVTKFI--NILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGS 502
            |.||..|.:.|.:  ...|.|           ::.|:|:.|...|:|.|.::.::.::.|...|.
Human   435 YLGTTTGSLHKAVVSGDSSAH-----------LVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGG 488

  Fly   503 LVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSLNSTKK------ 561
            :..||..:||....|:.|:..:||.||||.::..|..|:.           .:|||.|:      
Human   489 VWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLLSA-----------PNLNSWKQDMERGN 542

  Fly   562 ---AAA-----------------------------LLCPHIPRDAPGAETVSFVTMAPPPT--EE 592
               |.|                             |.|||:      :...|:.....|..  |.
Human   543 PEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCPHL------SALASYYWSHGPAAVPEA 601

  Fly   593 QKLLYSNVGSSQGNQPSLEQQPTGG--------DDFGLNKITLTSMDPDDIMPNLNDPQKSTASV 649
            ...:|:      |:...:.|...||        :.|....|:.. :|..|....| ||:.:....
Human   602 SSTVYN------GSLLLIVQDGVGGLYQCWATENGFSYPVISYW-VDSQDQTLAL-DPELAGIPR 658

  Fly   650 DEIKYAST---------------PSFMLLTTIVFFTFLVGGIAGICCVKAKSRLMEAQMDESHRN 699
            :.:|...|               |.|:.:|  |.|..::.| |.|..|.:..|.:.|:       
Human   659 EHVKVPLTRVSGGAALAAQQSYWPHFVTVT--VLFALVLSG-ALIILVASPLRALRAR------- 713

  Fly   700 HFGKPMQFKHQNTGKDINLLMGSNAYTTTQKTPNLDLEKDRSHECKNSTEHLEKELPCKTS 760
                         ||    :.|.......:|.|   |.::         :||:....|:||
Human   714 -------------GK----VQGCETLRPGEKAP---LSRE---------QHLQSPKECRTS 745

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema1bNP_001163178.1 Sema_1A 55..511 CDD:200498 147/462 (32%)
PSI 510..>537 CDD:214655 10/26 (38%)
SEMA4ANP_001180229.1 Sema_4A 55..495 CDD:200517 147/460 (32%)
PSI 496..541 CDD:214655 16/55 (29%)
Ig 566..638 CDD:353325 14/83 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 722..749 8/36 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3611
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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