DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and SEMA3F

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_004177.3	Gene:	SEMA3F / 6405	HGNCID:	10728	Length:	785	Species:	Homo sapiens

Alignment Length:	672	Identity:	198/672 - (29%)
Similarity:	305/672 - (45%)	Gaps:	125/672 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LSGLTIVAGWMPDVKPDLQTKQDKV-----------------LAHFIG---NSTDYFKIL-DHND 68
            ::||.:.|..:....|...| ||.:                 .|||..   |:|||..:| |.:.
Human     3 VAGLLLWASLLTGAWPSFPT-QDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDH 66

  Fly    69 EFVLVGAKDVIYNVSLNGL-KEIARLEWHSTDADRELCALKGKH-EWDCHNYLRVYALRPNGEVL 131
            :.:.||:||.:.::.|:.: :|...:.|.::....|.|.|.||. ..:|.|::|:........:.
Human    67 DRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLY 131

  Fly   132 LCGTNSYKPRCRHY--------TPVEVSSEEAGSAGHA--HAMR-------------YEVSRDVE 173
            :|||.:|.|.|.:.        ||...:....|....|  .|:|             .|..|...
Human   132 VCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYIFYLEPERLES 196

  Fly   174 AQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYR-----ENLRTEQYDLKQLNQPDFVGA 233
            .:|.|||.|..::..|..:..||:....||.|.|..|:|     ..:||:||:.:.||.|.|:.|
Human   197 GKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHA 261

  Fly   234 ------IERNGYVL-FFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCS 291
                  .|||...| |||||.|.|... ..|||:|:.|:|.||.||.......|::||||||.||
Human   262 ELIPDSAERNDDKLYFFFRERSAEAPQ-SPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCS 325

  Fly   292 VPGE--FPFYFDEIQAI---------SPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAA 345
            ||||  ...:|||:|.:         :|:        ||||||:|.:...|||||.:::.||...
Human   326 VPGEDGIETHFDELQDVFVQQTQDVRNPV--------IYAVFTSSGSVFRGSAVCVYSMADIRMV 382

  Fly   346 FDGEFKSQKDSQSHWLPVEREQVPKPRPGQC--------VEDSRTLTSIAVNFIKNHPLMEEAVP 402
            |:|.|..::.....|:|.. .::|.||||.|        ::.::......:||:::||||.:||.
Human   383 FNGPFAHKEGPNYQWMPFS-GKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVY 446

  Fly   403 AVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLK 467
            .:..|||:.:....:|||.||| .||.:..|. |:|::.|||.|.|.|.|.:    |... ..|:
Human   447 PLQRRPLVVRTGAPYRLTTIAV-DQVDAADGR-YEVLFLGTDRGTVQKVIVL----PKDD-QELE 504

  Fly   468 TVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPLHHC-SHIVDCLGCLSLQDPICAWD 531
            .:::.|::|.....|::.:.||:.:..|.|.|...:..:.||.| ::...|..|...:||.||||
Human   505 ELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWD 569

  Fly   532 LQTHECKNLATSQHK------------------FGTKTYLQSLNSTK-----KAAALLCPHIPRD 573
            .|.  |.....|..:                  |.:.....::.|.:     .||.|.|.  ||
Human   570 GQA--CSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFLECQ--PR- 629

  Fly   574 APGAETVSFVTMAPPPTEEQKL 595
            :|.| ||.::....|....:::
Human   630 SPQA-TVKWLFQRDPGDRRREI 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	163/515 (32%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	10/27 (37%)
SEMA3F	NP_004177.3	Sema_3F	48..548	CDD:200515	163/516 (32%)
		PSI	547..584	CDD:214655	12/38 (32%)
		Ig_Semaphorin_classIII	609..697	CDD:143279	12/46 (26%)
		IG_like	612..696	CDD:214653	12/43 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	752..785
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910