DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and SEMA4G

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_060363.2	Gene:	SEMA4G / 57715	HGNCID:	10735	Length:	843	Species:	Homo sapiens

Alignment Length:	766	Identity:	206/766 - (26%)
Similarity:	328/766 - (42%)	Gaps:	150/766 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LLITLSGLTIVAGWMP---------DVKPDLQTKQDKV--LAHFIGNSTDYFK-ILDHNDEFVLV 73
            ||:::...|.|.|  |         |..|.:....:::  ..||.|.:.:|.. :|:.....:||
Human     8 LLLSILTATAVPG--PSLRRPSRELDATPRMTIPYEELSGTRHFKGQAQNYSTLLLEEASARLLV 70

  Fly    74 GAKDVIYNVSLNGLKEIARLE--WHSTDADRELCALKGK-HEWDCHNYLRVYALRPNGEVLLCGT 135
            ||:..::::|.|.:.:.|..|  |.::...:..|..||| ::.:|.|::|......:..:..|||
Human    71 GARGALFSLSANDIGDGAHKEIHWEASPEMQSKCHQKGKNNQTECFNHVRFLQRLNSTHLYACGT 135

  Fly   136 NSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATV 200
            ::::|.|              :|..|.|.....|.: |.:..|||.||...|....||.||:||.
Human   136 HAFQPLC--------------AAIDAEAFTLPTSFE-EGKEKCPYDPARGFTGLIIDGGLYTATR 185

  Fly   201 ADFSGGDPLIYR----ENLRTEQYDLKQLNQPDFV----------GAIERNGYVLFFFRELSMEV 251
            .:|. ..|.|.|    .:||||:..:..||..:||          .|:..:..|.:||.|.:.|.
Human   186 YEFR-SIPDIRRSRHPHSLRTEETPMHWLNDAEFVFSVLVRESKASAVGDDDKVYYFFTERATEE 249

  Fly   252 MNFGKAVY---------SRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAIS 307
               |...:         :|||||||.|.||.....|.|||||||||.|.:|     .::.::.:.
Human   250 ---GSGSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTSFLKARLICHIP-----LYETLRGVC 306

  Fly   308 PI-VESGSKSLIYAVFTTSV--NAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVP 369
            .: .|:.|::..||.||.|.  ..:..||:|.:::.:|.|.|.|.:...:|....|...| ..||
Human   307 SLDAETSSRTHFYAAFTLSTQWKTLEASAICRYDLAEIQAVFAGPYMEYQDGSRRWGRYE-GGVP 370

  Fly   370 KPRPGQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVH 425
            :||||.|:.|         |:.|.|:.::|:|.||||...|....|||||.|.|:  |.|.:...
Human   371 EPRPGSCITDSLRSQGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNI--RYTHLTGT 433

  Fly   426 PQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVIST 490
            | |.:.:|..||:::.||.||.:.|.: :|.:..:         :|.|.||......:..||||.
Human   434 P-VTTPAGPTYDLLFLGTADGWIHKAV-VLGSGMH---------IIEETQVFRESQSVENLVISL 487

  Fly   491 SKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQS 555
            .::||.|.:...::.:||..||....|..|:..:||.|.||..||.|....|            .
Human   488 LQHSLYVGAPSGVIQLPLSSCSRYRSCYDCILARDPYCGWDPGTHACAAATT------------I 540

  Fly   556 LNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQK----------------------LLYS 598
            .|.::.:...|...|.|...|.|: |..|..|||.:.:.                      ||..
Human   541 ANRSQGSRTALIQDIERGNRGCES-SRDTGPPPPLKTRSVLRGDDVLLPCDQPSNLARALWLLNG 604

  Fly   599 NVGSSQGNQPSLEQQPTGGDDFGLNKITLTSMDPD---------------DIMPNLNDPQKSTAS 648
            ::|.|.|.         ||...|::.:.:|...|:               .::.:.:...:....
Human   605 SMGLSDGQ---------GGYRVGVDGLLVTDAQPEHSGNYGCYAEENGLRTLLASYSLTVRPATP 660

  Fly   649 VDEIKYASTPSFMLLTTI-VFFTFLVGGIAGICCVKAKSRLMEAQMDESHR 698
            ....|..:||...|...: :.:...:..:.|:|.:.|.|.|..|.:.|..|
Human   661 APAPKAPATPGAQLAPDVRLLYVLAIAALGGLCLILASSLLYVACLREGRR 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	150/494 (30%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	11/26 (42%)
SEMA4G	NP_060363.2	Sema_4G	47..506	CDD:200523	151/496 (30%)
		PSI	507..557	CDD:307546	16/61 (26%)
		Ig_Sema4B_like	572..655	CDD:143280	12/91 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	728..782
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910