Protein Alignment Sema1b and SEMA4G

DIOPT Version :10

• Sequence 1: NP_611244.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: NP_060363.2
• Gene: SEMA4G / 57715
• HGNCID: 10735
• Length: 843
• Species: Homo sapiens
• Alignment Length: 766
• Identity: 206/766 - (26%)
• Similarity: 328/766 - (42%)
• Gaps: 150/766 - (19%)

  Fly    21 LLITLSGLTIVAGWMP---------DVKPDLQTKQDKV--LAHFIGNSTDYFK-ILDHNDEFVLV 73
            ||:::...|.|.|  |         |..|.:....:::  ..||.|.:.:|.. :|:.....:||
Human     8 LLLSILTATAVPG--PSLRRPSRELDATPRMTIPYEELSGTRHFKGQAQNYSTLLLEEASARLLV 70

  Fly    74 GAKDVIYNVSLNGLKEIARLE--WHSTDADRELCALKGK-HEWDCHNYLRVYALRPNGEVLLCGT 135
            ||:..::::|.|.:.:.|..|  |.::...:..|..||| ::.:|.|::|......:..:..|||
Human    71 GARGALFSLSANDIGDGAHKEIHWEASPEMQSKCHQKGKNNQTECFNHVRFLQRLNSTHLYACGT 135

  Fly   136 NSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATV 200
            ::::|.|              :|..|.|.....|.: |.:..|||.||...|....||.||:||.
Human   136 HAFQPLC--------------AAIDAEAFTLPTSFE-EGKEKCPYDPARGFTGLIIDGGLYTATR 185

  Fly   201 ADFSGGDPLIYR----ENLRTEQYDLKQLNQPDFV----------GAIERNGYVLFFFRELSMEV 251
            .:|. ..|.|.|    .:||||:..:..||..:||          .|:..:..|.:||.|.:.|.
Human   186 YEFR-SIPDIRRSRHPHSLRTEETPMHWLNDAEFVFSVLVRESKASAVGDDDKVYYFFTERATEE 249

  Fly   252 MNFGKAVY---------SRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAIS 307
               |...:         :|||||||.|.||.....|.|||||||||.|.:|     .::.::.:.
Human   250 ---GSGSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTSFLKARLICHIP-----LYETLRGVC 306

  Fly   308 PI-VESGSKSLIYAVFTTSV--NAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVP 369
            .: .|:.|::..||.||.|.  ..:..||:|.:::.:|.|.|.|.:...:|....|...| ..||
Human   307 SLDAETSSRTHFYAAFTLSTQWKTLEASAICRYDLAEIQAVFAGPYMEYQDGSRRWGRYE-GGVP 370

  Fly   370 KPRPGQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVH 425
            :||||.|:.|         |:.|.|:.::|:|.||||...|....|||||.|.|:  |.|.:...
Human   371 EPRPGSCITDSLRSQGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNI--RYTHLTGT 433

  Fly   426 PQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVIST 490
            | |.:.:|..||:::.||.||.:.|.: :|.:..:         :|.|.||......:..||||.
Human   434 P-VTTPAGPTYDLLFLGTADGWIHKAV-VLGSGMH---------IIEETQVFRESQSVENLVISL 487

  Fly   491 SKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQS 555
            .::||.|.:...::.:||..||....|..|:..:||.|.||..||.|....|            .
Human   488 LQHSLYVGAPSGVIQLPLSSCSRYRSCYDCILARDPYCGWDPGTHACAAATT------------I 540

  Fly   556 LNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQK----------------------LLYS 598
            .|.::.:...|...|.|...|.|: |..|..|||.:.:.                      ||..
Human   541 ANRSQGSRTALIQDIERGNRGCES-SRDTGPPPPLKTRSVLRGDDVLLPCDQPSNLARALWLLNG 604

  Fly   599 NVGSSQGNQPSLEQQPTGGDDFGLNKITLTSMDPD---------------DIMPNLNDPQKSTAS 648
            ::|.|.|.         ||...|::.:.:|...|:               .::.:.:...:....
Human   605 SMGLSDGQ---------GGYRVGVDGLLVTDAQPEHSGNYGCYAEENGLRTLLASYSLTVRPATP 660

  Fly   649 VDEIKYASTPSFMLLTTI-VFFTFLVGGIAGICCVKAKSRLMEAQMDESHR 698
            ....|..:||...|...: :.:...:..:.|:|.:.|.|.|..|.:.|..|
Human   661 APAPKAPATPGAQLAPDVRLLYVLAIAALGGLCLILASSLLYVACLREGRR 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_611244.1	Sema_1A	55..511	CDD:200498	150/494 (30%)
		PSI	510..>537	CDD:214655	11/26 (42%)
SEMA4G	NP_060363.2	Sema_4G	47..506	CDD:200523	151/496 (30%)
		PSI	507..>534	CDD:396154	11/26 (42%)
		Ig_Sema4B_like	572..655	CDD:409456	12/91 (13%)
		Ig strand A	572..578	CDD:409456	2/5 (40%)
		Ig strand B	582..590	CDD:409456	0/7 (0%)
		Ig strand C	596..602	CDD:409456	0/5 (0%)
		Ig strand C'	604..607	CDD:409456	0/2 (0%)
		Ig strand D	614..618	CDD:409456	1/3 (33%)
		Ig strand E	620..627	CDD:409456	1/6 (17%)
		Ig strand F	633..642	CDD:409456	0/8 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	728..782