DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and SEMA6A

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_006714726.1	Gene:	SEMA6A / 57556	HGNCID:	10738	Length:	1052	Species:	Homo sapiens

Alignment Length:	854	Identity:	259/854 - (30%)
Similarity:	378/854 - (44%)	Gaps:	183/854 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 MILLITL---SGLTIVAGWMPDVKP-----DLQTKQDKV-LAHFIGNSTDYFKILDHNDEFVL-- 72
            ::|..||   :|    ||:..|.:|     ...|||..| :.|..|.:|.....||.....::
Human     6 LLLYFTLLHFAG----AGFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIMIMNG 66

  Fly    73 ---VGAKDVIYNVSL--NGLKEI---ARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGE 129
               :.|:|.||.|.:  :..:||   .:|.|.|..||.:.|.:||||:.:|||:::|...:.:..
Human    67 TLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDA 131

  Fly   130 VLLCGTNSYKPRCRHY---TPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFA 191
            :.:||||::.|.||:|   |......|.:|.|                  .|||...|.:...||
Human   132 LFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMA------------------RCPYDAKHANVALFA 178

  Fly   192 DGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEV 251
            ||.||||||.||...|.:|||.     .|||.::|.|.|.:|.||.|::...|:.|||||:::|.
Human   179 DGKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEY 243

  Fly   252 MNFGKAVYSRVARVCKNDRGGPYS-HGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVESGSK 315
            ...||.|:.|||:|||||.||... ..|.|||||||||||||||:..|||:.:||::.::....:
Human   244 NTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGR 308

  Fly   316 SLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCVEDS 380
            .::.|.|:|..|:||||||||:::.||.:.|.|.||.||...|.|.||..|:|||||||.|...|
Human   309 DVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSS 373

  Fly   381 ---RTLTS-----IAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAY-- 435
               |..||     ..:||||.||||:||||::..||...:..:.:|||.||    |.:.:|.|
Human   374 SLERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFLRTMVRYRLTKIA----VDTAAGPYQN 434

  Fly   436 YDVIYSGTDDGKVTKFINILSTHPNSTV--DRLKTVVISEMQVLPL------GTPIRELV---IS 489
            :.|::.|::.|.:.||   |:...||..  |.|   .:.||.|...      |...:.::   :.
Human   435 HTVVFLGSEKGIILKF---LARIGNSGFLNDSL---FLEEMSVYNSEKCSYDGVEDKRIMGMQLD 493

  Fly   490 TSKNSLVVVSDGSLVSVPLHHCSHIVDC-LGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYL 553
            .:.:||.|.....::.|||..|.....| ..|::.:||.|.|..:...|.:|:.:..    .|:.
Human   494 RASSSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWIKEGGACSHLSPNSR----LTFE 554

  Fly   554 QSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLY--------------------- 597
            |.:....           .|..|....|||.:     .|..:|:
Human   555 QDIERGN-----------TDGLGDCHNSFVAL-----NEANILFIMCMVIILQGWSFWSCWHSSS 603

  Fly   598 ---SNVGSSQGNQPSLEQQPTGGDDFGLNKITLTSMDPDDIM--PNLNDPQKSTASVD--EIKYA 655
               |...|....|...|.:  ||           .:|...::  |:..||..:.:|.:  :.|..
Human   604 LLPSTTTSDSTAQEGYESR--GG-----------MLDWKHLLDSPDSTDPLGAVSSHNHQDKKGV 655

  Fly   656 STPSFM----------LLTTIVFFTFLVG----GIAGIC-CVKAKSRLMEAQMDESHRNH----- 700
            ...|::          ||...|...|::|    ||...| |...:..:...|..|....|
Human   656 IRESYLKGHDQLVPVTLLAIAVILAFVMGAVFSGITVYCVCDHRRKDVAVVQRKEKELTHSRRGS 720

  Fly   701 ----------FGKPMQFKHQNTGKDINLLMGSNAYTTTQKTPNLDLEKDRSHECKNSTEHLE-KE 754
                      || ..|.|.......:..||.:....|...|..:.::.|:        .||: ..
Human   721 MSSVTKLSGLFG-DTQSKDPKPEAILTPLMHNGKLATPGNTAKMLIKADQ--------HHLDLTA 776

  Fly   755 LPCKTSTLT 763
            ||...||.|
Human   777 LPTPESTPT 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	187/495 (38%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	7/27 (26%)
SEMA6A	XP_006714726.1	Sema_6A	48..513	CDD:200527	185/492 (38%)
SEMA6A	XP_006714726.1	PSI	514..>544	CDD:307546	8/29 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1252
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2116
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8465
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.820