Protein Alignment Sema1b and SEMA6A

DIOPT Version :10

• Sequence 1: NP_611244.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: XP_006714726.1
• Gene: SEMA6A / 57556
• HGNCID: 10738
• Length: 1052
• Species: Homo sapiens
• Alignment Length: 854
• Identity: 259/854 - (30%)
• Similarity: 378/854 - (44%)
• Gaps: 183/854 - (21%)

  Fly    19 MILLITL---SGLTIVAGWMPDVKP-----DLQTKQDKV-LAHFIGNSTDYFKILDHNDEFVL-- 72
            ::|..||   :|    ||:..|.:|     ...|||..| :.|..|.:|.....||.....::
Human     6 LLLYFTLLHFAG----AGFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIMIMNG 66

  Fly    73 ---VGAKDVIYNVSL--NGLKEI---ARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGE 129
               :.|:|.||.|.:  :..:||   .:|.|.|..||.:.|.:||||:.:|||:::|...:.:..
Human    67 TLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDA 131

  Fly   130 VLLCGTNSYKPRCRHY---TPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFA 191
            :.:||||::.|.||:|   |......|.:|.|                  .|||...|.:...||
Human   132 LFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMA------------------RCPYDAKHANVALFA 178

  Fly   192 DGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEV 251
            ||.||||||.||...|.:|||.     .|||.::|.|.|.:|.||.|::...|:.|||||:::|.
Human   179 DGKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEY 243

  Fly   252 MNFGKAVYSRVARVCKNDRGGPYS-HGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVESGSK 315
            ...||.|:.|||:|||||.||... ..|.|||||||||||||||:..|||:.:||::.::....:
Human   244 NTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGR 308

  Fly   316 SLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCVEDS 380
            .::.|.|:|..|:||||||||:::.||.:.|.|.||.||...|.|.||..|:|||||||.|...|
Human   309 DVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSS 373

  Fly   381 ---RTLTS-----IAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAY-- 435
               |..||     ..:||||.||||:||||::..||...:..:.:|||.||    |.:.:|.|
Human   374 SLERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFLRTMVRYRLTKIA----VDTAAGPYQN 434

  Fly   436 YDVIYSGTDDGKVTKFINILSTHPNSTV--DRLKTVVISEMQVLPL------GTPIRELV---IS 489
            :.|::.|::.|.:.||   |:...||..  |.|   .:.||.|...      |...:.::   :.
Human   435 HTVVFLGSEKGIILKF---LARIGNSGFLNDSL---FLEEMSVYNSEKCSYDGVEDKRIMGMQLD 493

  Fly   490 TSKNSLVVVSDGSLVSVPLHHCSHIVDC-LGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYL 553
            .:.:||.|.....::.|||..|.....| ..|::.:||.|.|..:...|.:|:.:..    .|:.
Human   494 RASSSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWIKEGGACSHLSPNSR----LTFE 554

  Fly   554 QSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLY--------------------- 597
            |.:....           .|..|....|||.:     .|..:|:
Human   555 QDIERGN-----------TDGLGDCHNSFVAL-----NEANILFIMCMVIILQGWSFWSCWHSSS 603

  Fly   598 ---SNVGSSQGNQPSLEQQPTGGDDFGLNKITLTSMDPDDIM--PNLNDPQKSTASVD--EIKYA 655
               |...|....|...|.:  ||           .:|...::  |:..||..:.:|.:  :.|..
Human   604 LLPSTTTSDSTAQEGYESR--GG-----------MLDWKHLLDSPDSTDPLGAVSSHNHQDKKGV 655

  Fly   656 STPSFM----------LLTTIVFFTFLVG----GIAGIC-CVKAKSRLMEAQMDESHRNH----- 700
            ...|::          ||...|...|::|    ||...| |...:..:...|..|....|
Human   656 IRESYLKGHDQLVPVTLLAIAVILAFVMGAVFSGITVYCVCDHRRKDVAVVQRKEKELTHSRRGS 720

  Fly   701 ----------FGKPMQFKHQNTGKDINLLMGSNAYTTTQKTPNLDLEKDRSHECKNSTEHLE-KE 754
                      || ..|.|.......:..||.:....|...|..:.::.|:        .||: ..
Human   721 MSSVTKLSGLFG-DTQSKDPKPEAILTPLMHNGKLATPGNTAKMLIKADQ--------HHLDLTA 776

  Fly   755 LPCKTSTLT 763
            ||...||.|
Human   777 LPTPESTPT 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_611244.1	Sema_1A	55..511	CDD:200498	187/495 (38%)
		PSI	510..>537	CDD:214655	7/27 (26%)
SEMA6A	XP_006714726.1	Sema_6A	48..513	CDD:200527	185/492 (38%)
		PSI	514..>544	CDD:396154	8/29 (28%)