DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and sema4ba

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001121824.1	Gene:	sema4ba / 572261	ZFINID:	ZDB-GENE-070705-31	Length:	830	Species:	Danio rerio

Alignment Length:	558	Identity:	177/558 - (31%)
Similarity:	273/558 - (48%)	Gaps:	88/558 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ILDHNDEFVLVGAKDVIYNVSLNGLKEIAR------LEWHSTDADRELCALKGKH-EWDCHNYLR 120
            :|...|..:.|||::.::  :|| :.:|:|      |.|.:....|:.|:.|||. :.||.||::
Zfish    60 LLSKEDNMLYVGARETLF--ALN-ISDISRTQMQRNLTWSTPQRKRDECSFKGKDLKTDCFNYIK 121

  Fly   121 VYALRPNG-EVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQG--LCPYSP 182
            : .||.|. .:.:|||.::.|.|.:......|        :...:|.||...:...|  .|||:|
Zfish   122 I-LLRVNSTHLYVCGTYAFSPICTYIVSTNTS--------NFSLVRNEVGEIMTEDGRSRCPYNP 177

  Fly   183 AHNSTYAFADGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVG---------- 232
            .:.||...|||.||:.||::|.|.||:||:.     .|:||. .|..|..|.|||
Zfish   178 EYKSTAIMADGELYAGTVSNFQGNDPIIYKSLGQGTALKTEN-SLNWLQDPAFVGSAYIQESLPK 241

  Fly   233 --AIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGE 295
              |:..:..:.|||.|...|...|...:.||:|||||.|:||.....|.||:||||:|.||:|.:
Zfish   242 GNAVGDDDKIYFFFSEAGKEFDFFDNTIVSRIARVCKGDKGGERVLQKKWTTFLKAQLLCSLPDD 306

  Fly   296 -FPF-YFDEIQAISPIVESGSKSLIYAVFTTS--VNAIPGSAVCAFNVDDILAAFDGEFKSQKDS 356
             ||| ...::..::|..|...|::.|.|||:.  ..|...||||||.:|.:..||:|.::.....
Zfish   307 GFPFNIIQDMFVLTPSKEDWKKTMFYGVFTSQWYKGASGSSAVCAFTMDQVEEAFNGRYREVNRE 371

  Fly   357 QSHWLPVEREQVPKPRPGQCVEDSRTLTSIA---------VNFIKNHPLMEEAVPAVHGRPLLTK 412
            ...|. .....||:||||.|:.::.....|:         :||:|:|.||:.   .:..:|||.|
Zfish   372 TQQWY-TYNHPVPEPRPGACITNTARAQGISSSLHMPDRVLNFVKDHFLMDN---VIRSQPLLLK 432

  Fly   413 VNLHHRLTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVL 477
            .|:  |.|.:||| :|::|... |||::.|||||::.|.||:          :.|..:|.|:.:.
Zfish   433 RNV--RYTQLAVH-RVQALHKT-YDVLFIGTDDGRIHKAINV----------KNKMYIIEELVIF 483

  Fly   478 PLGTPIRELVISTSKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLAT 542
            |....::.:.:...|..|.|.|...||.:||.:||:...|..|:..:||.|||  ...:|.|:
Zfish   484 PEPQSVQHIELDDEKGLLFVSSYSGLVEIPLANCSNYQSCGECVLSRDPYCAW--TGKQCSNV-- 544

  Fly   543 SQHKFGTKTYLQSLNSTKKAAALLC---------PHIP 571
             :|......:.|.:.....|   :|         |.:|
Zfish   545 -KHASSKSQWQQDVEDANTA---ICKMPSPRSGRPRVP 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	160/487 (33%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	9/26 (35%)
sema4ba	NP_001121824.1	Sema_4B	47..515	CDD:200518	159/485 (33%)
		PSI	516..565	CDD:214655	14/56 (25%)
		Ig	578..654	CDD:299845	1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010