DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and sema4ab

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_005170153.1	Gene:	sema4ab / 571290	ZFINID:	ZDB-GENE-060503-363	Length:	836	Species:	Danio rerio

Alignment Length:	767	Identity:	204/767 - (26%)
Similarity:	323/767 - (42%)	Gaps:	148/767 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ILDHNDEFVL-VGAKDVIYNVSLN----GLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVY 122
            :|..|||..| |||:|.|.:::::    .|||  :|:|..::.|...|::|||.:.||||::||.
Zfish    52 LLLSNDEGTLFVGARDTILSINISQTDMTLKE--KLDWSPSEKDFNDCSMKGKLKMDCHNFVRVL 114

  Fly   123 ALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEE----AGSAGHAHAMRYEVSRDVEAQGLCPYSPA 183
            .:..:..:..|||.::.|||     :.::|:.    .|.:|          :..|.:|.|||.|.
Zfish   115 QVLNSTHMYACGTFAFSPRC-----IYINSQTFTMVTGPSG----------KPEEGRGRCPYDPY 164

  Fly   184 HNSTYAFADGHLYSATVADFSGGDPLIYRENLRTEQYDLK------QLNQPDFVGA--IERNGYV 240
            ..::....||.||:.||:||.|..|:|.|........|||      .|..|.|:.:  |.....|
Zfish   165 QKNSAITVDGELYTGTVSDFRGTRPVISRHLSEGSHVDLKLDDTLGWLEDPTFISSTYIHSEEKV 229

  Fly   241 LFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYF--DEI 303
            .|||.|:..|.....|...||||:||.:|.||..:..|.||:|.||:|.|....|.|:..  |.|
Zfish   230 YFFFSEIGKEYDFIDKFTVSRVAQVCTSDVGGQRTLQKRWTTFAKAQLLCQADQELPYNVLQDVI 294

  Fly   304 QAISPIVESGSKSLIYAVFTTS--VNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVERE 366
            ....|...|..::|.|.:||:.  || :..||||||::.||...|.|.:|........|....:|
Zfish   295 SLSPPEGASEDETLFYGIFTSQWRVN-LGRSAVCAFSLKDIKKVFTGRYKVLNRDTLKWSTRVQE 358

  Fly   367 QVPKPRPGQCVEDSRTLTSIAVNFIKNHPLMEEAV-PAVHGRPLLTKVNLHHRLTAIAVHPQVKS 430
            |:  ..||:|  .....:...:.|:|::.|.:::| |...|   ||.|:.....:.||.. :|:.
Zfish   359 QM--ANPGEC--GLHNASDNTLRFVKDNFLADKSVLPVNQG---LTVVSPDKSYSNIAAQ-RVQG 415

  Fly   431 LSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTV-------VISEMQVLPLGTPIRELVI 488
            ..|.||.|:|..|:.|    |::             |||       :|.|:||......::.|::
Zfish   416 ARGKYYTVLYLLTESG----FLH-------------KTVLLKKGAHIIEEIQVFHQPQMVKSLLL 463

  Fly   489 STSKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFG----- 548
            |.||.::::.|...|:|||:.:|||...|..|:..:||.|.|||....||.:.|||::..
Zfish   464 SVSKGAVLIGSSEGLLSVPVSNCSHYRSCAECVLARDPFCGWDLSQRVCKLITTSQNQLAQDVDE 528

  Fly   549 -------TKTYLQSLNSTKKAAALLCPHIPRDAPGA-------ETVSFVTMAPPPTEEQKLLYSN 599
                   :...|:|.:...:....|||      ||.       |.::.  ..|..:...|..:..
Zfish   529 GKVSEQCSSVNLRSRSGQPQNTQTLCP------PGEVLSVSLNEVINL--QCPEASNLAKCHWER 585

  Fly   600 VGSSQGNQPSLEQQPTGGDDFGLNKITLTSMDPDDIMPNLNDPQKSTASVDEIKYASTPSFMLLT 664
            :.|..  .|.:..|...|   .|:.:...|.....:...:.:....|..|..||..:.|:.:
Zfish   586 LNSQL--SPKIFIQSVNG---SLSFVATPSTLGHYLCQAVENGYTQTLIVYHIKQKNNPTIL--- 642

  Fly   665 TIVFFTFLVGGIAGICCVKAKSRLMEAQMDESHRNHFGKPMQFKHQN------------TGKDIN 717
                              .:..::.....:..::..|..|...||..            ..||
Zfish   643 ------------------PSSPKITPTSAEAGNKTPFSTPTAPKHTELRPKPEDPSSTVAHKD-- 687

  Fly   718 LLMGSNAYTTTQK----TPNLDLEKDRSHECKNSTEHLEKELPCKTSTLTKV 765
                 :..|||:|    ||.:..|::.|...:.|....:.:.|.....|..|
Zfish   688 -----SPATTTRKSKNFTPLISAEEESSWMNERSGNFKQVDKPTYLQELVVV 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	149/476 (31%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	11/26 (42%)
sema4ab	XP_005170153.1	Sema_4	41..484	CDD:200501	149/474 (31%)
		PSI	485..>512	CDD:214655	11/26 (42%)
		Ig	555..631	CDD:299845	13/88 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910